, Volume 88, Issue 4, pp 379-381
Date: 16 Aug 2008

Splenic marginal zone B-cell lymphoma in a HIV-positive patient: a case report

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Dear Editor,

A 47-year-old man was hospitalized in November 2006 for hyperthermia into the Division of Tropical Infectious Diseases. The patient had been diagnosed with HIV infection 14 years before and was in antiretroviral therapy since 9 years; his CD4-positive cells ranged between 300 and 650 cells per microliter and viral load remained less than <50 copies per microliter with didanosine, lamivudine, and atazanavir. Since the diagnosis, he did not show any relevant HIV-related clinical event.

At admission, the physical exam revealed organic decay, weight loss, multiple small superficial adenopathies and marked splenomegaly (spleen palpable in left iliac region). The patient was initially treated with antipyretics, hydration, and continued antiretroviral therapy.

The blood cell count showed white blood cells 3,840 per microliter (lymphocytes 66%, absolute count 2,534 per microliter), platelets 1,233,000 per microliter, and hemoglobin 10.3 g/dl. The biochemistry showed lactate dehydroge