, Volume 87, Issue 8, pp 681-682,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 03 Apr 2008

Histiocytic sarcoma localised in the thyroid—a case report

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Dear Editor,

Histiocytic sarcoma” is a rare haematological neoplasm with immunohistochemical and morphological diagnostic criteria per exclusionem. In this case report, our patient illustrates that this rare tumour with its unique location and diagnostic morphologic criteria is sensitive to a combination of anthracycline-based chemotherapy and radiotherapy, resulting in complete response for 2 years.

A 64-year-old Caucasian woman presented with an asymptomatic, gradually enlarging neck mass at the Outpatient Department of Internal Medicine. Laboratory results showed subclinical hypothyroidism. Thyroid scintigraphy revealed a cold nodule in the left lower thyroid lobe. Results of aspiration cytology were compatible with an infected cyst. Based on the presence of a goitre, subclinical hypothyroidism and auto-antithyroid peroxidase antibodies >600 kU/L, a diagnosis of Hashimoto’s thyroiditis was suspected and treated with levothyroxin. Five months later she developed neck pain. Pre-operati ...