Annals of Hematology

, Volume 87, Issue 6, pp 475–480

High prevalence of occult hepatitis B virus infection in patients with B cell non-Hodgkin’s lymphoma

  • Ming-Huang Chen
  • Liang-Tsai Hsiao
  • Tzeon-Jye Chiou
  • Jin-Hwang Liu
  • Jyh-Pyng Gau
  • Hao-Wei Teng
  • Wei-Shu Wang
  • Ta-Chung Chao
  • Chueh-chuan Yen
  • Po-Min Chen
Original Article

DOI: 10.1007/s00277-008-0469-9

Cite this article as:
Chen, M., Hsiao, L., Chiou, T. et al. Ann Hematol (2008) 87: 475. doi:10.1007/s00277-008-0469-9

Abstract

Several reports recently found that patients with B cell non-Hodgkin’s lymphoma (NHL) had a higher carrier rate of hepatitis B surface antigen (HBsAg). The current study aimed to examine the hepatitis B virus (HBV) infection status of NHL patients in Taiwan, an HBV-endemic area. Serum HBV and serum hepatitis C virus were measured in 471 NHL patients and 1,013 non-lymphoma cancer patients enrolled between February 2000 and March 2007. Furthermore, nested polymerase chain reaction of HBV-DNA was used to examine the sera from selected patients in these two populations and healthy volunteers for the presence of occult HBV infection. The infection rates (as indicated by the rates of HBsAg and occult HBV) were compared between different groups. There was a higher incidence of HBV infection in B cell NHL patients (23.5%), especially patients with diffuse large B lymphoma, than solid tumor patients (15.6%, P = 0.001). Among HbsAg-negative patients, those with B cell NHL had a higher prevalence of occult HBV infection (6%) than those with non-lymphoma solid tumors and healthy volunteers, 0% and 0.9%, respectively (P = 0.005). B cell NHL patients, even HBsAg-negative B cell NHL patients, but not T cell NHL patients, have a higher incidence of HBV infection than patients with solid tumors. Our findings support the etiologic role of HBV infection in B cell NHL.

Keywords

Hepatitis B virusNon-Hodgkin’s lymphomaOccult hepatitis B

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Ming-Huang Chen
    • 1
    • 2
  • Liang-Tsai Hsiao
    • 1
    • 2
  • Tzeon-Jye Chiou
    • 1
    • 2
  • Jin-Hwang Liu
    • 1
    • 2
  • Jyh-Pyng Gau
    • 1
    • 2
  • Hao-Wei Teng
    • 1
    • 2
  • Wei-Shu Wang
    • 1
    • 2
  • Ta-Chung Chao
    • 1
    • 2
  • Chueh-chuan Yen
    • 1
    • 2
  • Po-Min Chen
    • 1
    • 2
  1. 1.Division of Hematology & Oncology, Department of MedicineTaipei Veterans General HospitalTaipeiTaiwan
  2. 2.National Yang-Ming University School of MedicineTaipeiTaiwan