Annals of Hematology

, Volume 86, Issue 12, pp 897–903

Positron emission tomography in the staging of patients with Hodgkin’s lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi

Authors

    • Hematology and Nuclear MedicineCareggi Hospital and University of Florence
    • Department of HematologyUniversity of Florence
  • Umberto Vitolo
    • Hematology and Nuclear MedicineHospital S. Giovanni Battista
  • Luca Nassi
    • Hematology and Nuclear MedicineCareggi Hospital and University of Florence
  • Francesco Merli
    • Hematology and Nuclear MedicineArcispedale S. Maria Nuova
  • Andrea Gallamini
    • Hematology and Nuclear MedicineHospital S. Croce e` Carle
  • Patrizia Pregno
    • Hematology and Nuclear MedicineHospital S. Giovanni Battista
  • Isabel Alvarez
    • Hematology and Nuclear MedicineArcispedale S. Maria Nuova
  • Flavia Salvi
    • HematologyHospital SS. Antonio e Biagio
  • Rosaria Sancetta
    • Hematology and Nuclear MedicineHospital SS. Giovanni e Paolo
  • Antonio Castagnoli
    • Hematology and Nuclear MedicineCareggi Hospital and University of Florence
  • Annibale Versari
    • Hematology and Nuclear MedicineArcispedale S. Maria Nuova
  • Alberto Biggi
    • Hematology and Nuclear MedicineHospital S. Croce e` Carle
  • Michele Gregianin
    • Hematology and Nuclear MedicineHospital SS. Giovanni e Paolo
  • Ettore Pelosi
    • Hematology and Nuclear MedicineHospital S. Giovanni Battista
  • Teodoro Chisesi
    • Hematology and Nuclear MedicineHospital SS. Giovanni e Paolo
  • Alberto Bosi
    • Hematology and Nuclear MedicineCareggi Hospital and University of Florence
  • Alessandro Levis
    • HematologyHospital SS. Antonio e Biagio
  • On behalf of Intergruppo Italiano Linfomi
Original Article

DOI: 10.1007/s00277-007-0356-9

Cite this article as:
Rigacci, L., Vitolo, U., Nassi, L. et al. Ann Hematol (2007) 86: 897. doi:10.1007/s00277-007-0356-9

Abstract

In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin’s lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL from six Italian centers were enrolled in this study. They were staged with conventional methods; 2-[fluorine-18]fluoro-2-deoxy-d-glucose PET scanning were prospectively compared to CT. CT and FDG-PET stages were concordant in 156 patients (84%) and discordant in 30 patients (16%). PET stage in comparison to CT stage was higher in 27 patients (14%) and lower in 3 patients (1%). The programmed treatment strategy was modified in 11 out of 30 patients (37%) after the definition of final stage. If we considered the 123 CT staged patients with localized stage, ten patients (8%) with a change of stage from localized to advanced after PET evaluation were treated with different strategy. FDG-PET was shown to be a relevant, non-invasive method that supplements conventional procedures and should therefore be used routinely to stage HL, particularly in early stage patients, where a change in stage may modify disease management.

Keywords

Computed tomographyFDG-PET Hodgkin’s diseaseStaging

Copyright information

© Springer-Verlag 2007