Annals of Hematology

, Volume 86, Issue 2, pp 81–87

Results of a national consensus workshop: therapeutic algorithm in patients with follicular lymphoma—role of radioimmunotherapy

  • M. Dreyling
  • L. Trümper
  • C. von Schilling
  • M. Rummel
  • U. Holtkamp
  • A. Waldmann
  • J. Wehmeyer
  • M. Freund
Original Article

DOI: 10.1007/s00277-006-0207-0

Cite this article as:
Dreyling, M., Trümper, L., von Schilling, C. et al. Ann Hematol (2007) 86: 81. doi:10.1007/s00277-006-0207-0

Abstract

Radioimmunotherapy (RIT) was approved for the treatment of relapsed or refractory CD20-positive follicular lymphoma (FL), subsequent to rituximab containing primary therapy. However, an increasing number of clinical studies have suggested that RIT may be more efficacious in an earlier phase of the disease. Therefore, a consensus meeting was held in May 2005 to define the optimal setting of RIT in the therapeutic algorithm of patients with advanced stage of FL. RIT is an established therapeutic option in relapsed FL. According to the reviewed data, RIT should be preferably used as consolidation after initial tumor debulking. First-line RIT may be applied in patients not appropriate for chemotherapy induction. Current study concepts evaluate the role of RIT consolidation in combination with antibody maintenance to achieve a potentially curative approach even in patients with advanced stage disease.

Keywords

Radioimmunotherapy Follicular lymphoms Therapeutic algorithm 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • M. Dreyling
    • 1
  • L. Trümper
    • 2
  • C. von Schilling
    • 3
  • M. Rummel
    • 4
  • U. Holtkamp
    • 5
  • A. Waldmann
    • 5
  • J. Wehmeyer
    • 6
  • M. Freund
    • 7
  1. 1.Department of Medicine III, GrosshadernLudwig Maximilians UniversityMunichGermany
  2. 2.Department of Hematology and OncologyUniversity of GöttingenGöttingenGermany
  3. 3.Department of Hematology and OncologyTechnical University of MunichMunichGermany
  4. 4.Medical Clinic IIIUniversity of FrankfurtFrankfurt MainGermany
  5. 5.German Leukemia and Lymphoma Help (DLH)BonnGermany
  6. 6.MünsterGermany
  7. 7.Department of Hematology and OncologyUniversity of RostockRostockGermany