Annals of Hematology

, Volume 85, Issue 8, pp 535–541

HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: a retrospective analysis on 53 transplant candidates (1989–2003)

  • Margaret H. L. Ng
  • K. M. Lau
  • B. R. Hawkins
  • K. W. Chik
  • Natalie P. H. Chan
  • W. S. Wong
  • K. S. Tsang
  • Matthew M. K. Shing
  • C. K. Li
Original Article

DOI: 10.1007/s00277-006-0118-0

Cite this article as:
Ng, M.H.L., Lau, K.M., Hawkins, B.R. et al. Ann Hematol (2006) 85: 535. doi:10.1007/s00277-006-0118-0

Abstract

We performed a retrospective analysis on the human leukocyte antigen (HLA) data of 53 consecutive Chinese patients with high-risk childhood acute lymphoblastic leukemia (ALL) diagnosed from 1989 to 2003. A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31–100.36; p=0.0042; for statistical significance after Bonferroni correction (Bc) pBc<0.0083] was identified after Bonferroni correction. Although not surviving the Bonferroni correction, gender effects on the association were also observed with HLA-A11, HLA-A32, HLA-A33, and HLA-B22, which were however more prevalent in the female patients and particularly those developing relapse. Two patients with HLA-A29 and HLA-B7 revealed significantly shortened survivals, suggestive of their potential prognostic impacts. Notably, for the first time, we found a significant correlation of leukocyte count with HLA types, where HLA-A33 (p=0.006) or HLA-B17 (p<0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL.

Keywords

Acute lymphoblastic leukemia HLA Hong Kong Chinese Transplant candidates 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Margaret H. L. Ng
    • 1
  • K. M. Lau
    • 1
  • B. R. Hawkins
    • 2
  • K. W. Chik
    • 3
    • 4
  • Natalie P. H. Chan
    • 1
  • W. S. Wong
    • 1
  • K. S. Tsang
    • 1
  • Matthew M. K. Shing
    • 3
    • 4
  • C. K. Li
    • 3
    • 4
  1. 1.Hematology Section, Department of Anatomical & Cellular PathologyThe Chinese University of Hong Kong, Prince of Wales HospitalShatinPeople’s Republic of China
  2. 2.Department of PathologyQueen Mary HospitalHong Kong SARPeople’s Republic of China
  3. 3.Department of PediatricsThe Chinese University of Hong Kong, Prince of Wales HospitalShatinPeople’s Republic of China
  4. 4.Children Cancer CenterThe Chinese University of Hong Kong, Prince of Wales HospitalShatinPeople’s Republic of China

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