Annals of Hematology

, 85:327

Zygomycoses in patients with acute leukaemia

  • Enrico Schalk
  • Martin Mohren
  • Kathleen Jentsch-Ullrich
  • Frank Dombrowski
  • Astrid Franke
  • Michael Koenigsmann
Original Article

DOI: 10.1007/s00277-006-0082-8

Cite this article as:
Schalk, E., Mohren, M., Jentsch-Ullrich, K. et al. Ann Hematol (2006) 85: 327. doi:10.1007/s00277-006-0082-8

Abstract

Zygomycoses are rare invasive mould infections which mainly occur in immunocompromised patients, especially during prolonged neutropenia. The high mortality rate is due to a high failure rate of both intravital diagnosis and treatment. Exact diagnosis requires microscopic examination and proof by culture. The treatment consists of amphotericin B and surgical debridement. We report four recent cases of zygomycosis among 89 patients with intensively treated acute leukaemia at our institution. Three cases were breakthrough infections since the patients were under voriconazole treatment prior to diagnosis of zygomycosis. Only one patient had premortal diagnosis (paranasal sinus infection) and showed clinical response with amphotericin B and surgical debridement. A review of the literature of these emerging fungal infections is given and is focused on patients with acute leukaemia. In addition, the importance of autopsy as a tool for quality control and epidemiological studies is pointed out.

Keywords

Zygomycosis Acute leukaemia Voriconazole Neutropenic fever Breakthrough infection 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Enrico Schalk
    • 1
  • Martin Mohren
    • 1
  • Kathleen Jentsch-Ullrich
    • 1
  • Frank Dombrowski
    • 2
  • Astrid Franke
    • 1
  • Michael Koenigsmann
    • 1
  1. 1.Division of Haematology/Oncology, Department of Internal MedicineUniversity Hospital of MagdeburgMagdeburgGermany
  2. 2.Institute of PathologyUniversity Hospital of MagdeburgMagdeburgGermany

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