Annals of Hematology

, Volume 84, Issue 8, pp 553–554

An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma

Authors

    • Department of Laboratory MedicineGyeongsang National University Hospital
  • Gyeong-Won Lee
    • Department of Internal MedicineGyeongsang National University Hospital
  • Kook-Young Maeng
    • Department of Laboratory MedicineGyeongsang National University Hospital
Letter to the Editor

DOI: 10.1007/s00277-005-1042-4

Cite this article as:
Kim, M., Lee, G. & Maeng, K. Ann Hematol (2005) 84: 553. doi:10.1007/s00277-005-1042-4

Precursor T-acute lymphoblastic leukemia/lymphoma (ALL) comprises approximately 20–25% of adult cases of ALL. Precursor T-ALL tends to present in adolescent males as lymphomas and is characteristically presented with a high leukocyte count or large mediastinal mass at initial presentation. We report here a rare manifestation of precursor T-ALL presenting with clinically significant involvement of ovary and spine at initial presentation.

A 33-year-old woman presented with low abdominal pain and lumbago for 1 day in July 2004. Physical examination revealed tenderness in the right lower abdominal region. No enlarged spleen, liver or lymph nodes was palpable. Hematologic data showed Hb level of 8.3 g/dl, 8.91×109/l of WBC with 87% of segmented neutrophils, 10% of lymphocytes, 3% of monocytes, and 328×109/l of platelets. An ultrasound examination of the pelvis revealed a cystic mass with a dimension of 6.5×4.5 cm2 in the right ovary. An emergent operation was performed for presumed symptomatic ovarian cyst. Ovarian masses were solid masses rather than cystic masses under the laparotomy, and right salpingooophorectomy with left ovary wedge resection was done. Histologic examination of the ovarian masses revealed lymphoblastic infiltration (Fig. 1a). They showed positive immunoreactivity for CD3 (cytoplasmic pattern), CD10 and CD45 (leukocyte common antigen) and negative immunoreactivity for CD20, CD30, CD117 and CD68. On the fourth postoperative day the patient developed abrupt-onset paraplegia and sensory loss of both lower extremities. Magnetic resonance imaging of the spine showed a dorsal epidural mass destroying from T9 to T12, and multiple enhancing lesions in L3, L4, S1 vertebral body were revealed (Fig. 1b). Emergency operative decompression of the spinal cord was done to relieve the lower extremity paraplegia. Autogenous iliac bone graft and from T7 to T12 posterolateral fusion following T9, 10, 11 total and T8 partial decompressive laminectomy was done after the removal of epidural mass. Histologic examination of the spinal mass revealed lymphoblastic and eosinophilic infiltration (Fig. 1c). The lymphoblasts were characterized by positive immunoreactivity for CD3 (cytoplasmic pattern), CD10 and CD45 (leukocyte common antigen) and negative immunoreactivity for CD20, CD30, CD117 and CD68. Under the impression of T lymphoblastic lymphoma, bone marrow examination was done. The bone marrow touch imprint preparation showed that 92% of marrow cells were lymphoblasts. They were variable in size and characterized by high nuclear–cytoplasmic ratio (Fig. 1d). Trephine biopsy showed diffuse infiltration of marrow by lymphoblasts, which revealed numerous mitotic figures (Fig. 1e). Immunohistochemical stain showed positive reactivity for CD3 (cytoplasmic pattern) and negative for CD20 (Fig. 1f). Chromosomal analysis of bone marrow demonstrated a 46XX karyotype in 100% (20/20) of the cells. A CT scan of the chest demonstrated an anterior mediastinal mass approximately 12×8 cm2. A diagnosis of precursor T-ALL was made. The patient was started on induction chemotherapy with vincristine, prednisone, daunorubicin and l-asparaginase (VPDL). The anterior mediastinal mass regressed substantially and revealed a focal streaky density on follow-up chest CT checked on 28 June 2004. In August 2004, remission was successfully achieved as shown by follow-up bone marrow examination. The patient subsequently received further consolidation VPDL therapy and currently remains in good health.
Fig. 1

a The sections of a ovary showing infiltration of lymphoblasts, H&E, ×400; b spine MRI demonstrating dorsal epidural mass and multiple enhancing lesions in vertebral bodies; c The section of epidural mass showing infiltratin of lymphoblasts and eosinophils, H&E, ×400; d Bone marrow touch imprint preparation showing lymphoblasts, Wright, ×1000; e Bone marrow biopsy section showing extensive infiltration of lymphoblasts with mitotic fugures, H&E, ×400; f The lymphoblasts showing cytoplasmic CD3 positivity in a bone marow biopsy section, Immunoperoxidase for CD3, ×400

Precursor T-ALL is associated with numerous unfavorable presenting features; thus, patients have a worse prognosis than patients with precursor B-ALL. In adults, higher white blood cell counts (>30,000/μl) and older age (>60 years) shorten durations of remissions and overall survival and are considered as poor prognostic factors [2]. Immunophenotypically compared with patients with precursor T-ALL whose leukemic cells were CD10−, patients whose cells were CD10+ were more likely to achieve remission and have significantly improved event-free survival outcomes.

Incidentally identified lymphoma involving the female reproductive systems at autopsy is not uncommon. The involvement of the female reproductive systems and spine is quite rare in acute leukemia. An ovarian mass rarely may be the presenting feature of granulocytic sarcoma in acute leukemia, in particular acute myelomonocytic leukemia [1]. The involvement of the female reproductive systems and spine by ALL are distinctly rare either at initial presentation or relapse. Recently, a case of precursor B-ALL presented with ovarian mass and thrombocytopenia was reported [4]. Mark et al. and Zutter et al. reported the involvement of the female reproductive systems in precursor T-ALL in relapsing cases [3, 5]. We report here a case of precursor T-ALL presenting with symptomatic involvement of the female reproductive systems and spine at initial presentation. This case shows the necessity of considering the female reproductive tract and spine as a possible location of precursor T-ALL at initial presentation.

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© Springer-Verlag 2005