Review Article

Annals of Hematology

, Volume 84, Issue 4, pp 207-216

Recent developments in the management of invasive fungal infections in patients with hematological malignancies

  • Meinolf KarthausAffiliated withMedizinische Klinik II, Evangelisches Johannes-Krankenhaus Email author 
  • , Oliver A. CornelyAffiliated withKlinik I für Innere Medizin, Universität zu Köln

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Despite recent advances in the last decade, invasive fungal infections are still associated with a high morbidity and mortality. Invasive fungal infections constitute severe infectious complications in patients with hematological malignancies receiving myelosuppressive chemotherapy or sustained immunosuppression after allogeneic transplant regimens. Following a long period of stagnation, considerable progress has been made during the last 5 years in non-culture-based diagnostics and in the treatment of invasive fungal infections. This review highlights recent developments in the epidemiology, diagnosis, and treatment in the context of state-of-the-art management of invasive fungal infections in cancer patients.


Invasive fungal infection Aspergillosis Antigen assay Antifungals Azoles Echinocandins Candida Infection