Annals of Hematology

, Volume 83, Issue 7, pp 460–463

Primary adrenal lymphoma presenting as Addison’s disease: case report and review of the literature


  • George Mantzios
    • Hematology DepartmentMetropolitan Hospital
    • Hematology DepartmentMetropolitan Hospital
  • Filio Veliou
    • Hematology DepartmentMetropolitan Hospital
  • Iosif Boutsikakis
    • Internal Medicine DepartmentMetropolitan Hospital
  • Lillian Petraki
    • Histopathology DepartmentMetropolitan Hospital
  • John Kolovos
    • Radiology DepartmentMetropolitan Hospital
  • Sotirios Papageorgiou
    • Hematology DepartmentMetropolitan Hospital
  • Yannis Robos
    • Hematology DepartmentMetropolitan Hospital
Case Report

DOI: 10.1007/s00277-003-0838-3

Cite this article as:
Mantzios, G., Tsirigotis, P., Veliou, F. et al. Ann Hematol (2004) 83: 460. doi:10.1007/s00277-003-0838-3


Primary adrenal lymphoma (PAL) is an extremely rare entity and adrenal insufficiency is a common complication. Bilateral enlargement of adrenal glands should raise the suspicion of lymphoma, especially in patients with clinical or laboratory features of adrenal insufficiency. Most of these cases are highly aggressive tumors and should be treated with multiagent chemotherapy. The role of bilateral adrenalectomy and/or radiotherapy cannot be estimated. Our patient with PAL was an 80-year-old man who presented with clinical and laboratory features of adrenal insufficiency. Combination chemotherapy plus rituximab was unsuccessful and our patient died from progressive disease.


Adrenal lymphomaAddison’s diseaseExtranodal lymphoma

Copyright information

© Springer-Verlag 2004