Annals of Hematology

, Volume 83, Issue 6, pp 381–385

Acute megakaryoblastic leukaemia with extreme thrombocytosis and p190bcr/ablrearrangement

Case Report

DOI: 10.1007/s00277-003-0783-1

Cite this article as:
Balatzenko, G., Guenova, M., Zechev, J. et al. Ann Hematol (2004) 83: 381. doi:10.1007/s00277-003-0783-1
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Abstract

Acute megakaryoblastic leukaemia (AML-M7) is an uncommon disease, composing 0.5–1.2% of newly diagnosed adult acute myeloid leukaemias (AML). It is characterised by higher incidence and complexity of cytogenetic abnormalities. We report a rare case of Philadelphia (Ph) chromosome-positive AML-M7, presenting with extreme thrombocytosis and having a poor outcome. The diagnosis was established on the basis of morphological and flow cytometry data for megakaryoblastic proliferation in the bone marrow. Cytogenetics revealed 47,XX,+8,t(9;22)(q34;q11), and p190BCR-ABL-rearrangement was detected. MDR1-gene overexpression was not demonstrated; however, the patient was resistant to therapy and died in 6 months. The reported case contributes to the overt heterogeneity of Ph-positive AMLs, which warrants further investigation and understanding.

Keywords

Acute myeloid leukaemia Megakaryoblast p190BCR-ABL Philadelphia chromosome Thrombocytosis 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • G. Balatzenko
    • 2
  • M. Guenova
    • 1
  • J. Zechev
    • 3
  • S. Toshkov
    • 2
  1. 1.Laboratory of Cytopathology and HistopathologyNational Center of Haematology and TransfusiologySofiaBulgaria
  2. 2.Laboratory of Cytogenetics and Molecular BiologyNational Center of Haematology and TransfusiologySofiaBulgaria
  3. 3.Department of Clinical HaematologyNational Center of Haematology and TransfusiologySofiaBulgaria

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