Annals of Hematology

, Volume 82, Supplement 2, pp S141–S148

Diagnosis of invasive fungal infections in hematology and oncology

Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
  • M. Ruhnke
  • A. Böhme
  • D. Buchheidt
  • K. Donhuijsen
  • H. Einsele
  • R. Enzensberger
  • A. Glasmacher
  • H. Gümbel
  • C.-P. Heussel
  • M. Karthaus
  • E. Lambrecht
  • T. Südhoff
  • H. Szelényi
Article

DOI: 10.1007/s00277-003-0768-0

Cite this article as:
Ruhnke, M., Böhme, A., Buchheidt, D. et al. Ann Hematol (2003) 82(Suppl 2): S141. doi:10.1007/s00277-003-0768-0

Abstract

Invasive fungal infections are a primary cause of morbidity and mortality in patients with hematological malignancies. Establishing a definite diagnosis of invasive fungal infection in febrile neutropenic patients is particularly challenging and time-consuming, but a delay of antifungal treatment leads to higher mortality. This situation has lead to the strategy of initiation "empirical" antifungal therapy prior to the detection of fungi. Meanwhile, improvements in diagnostic procedures are achieved, especially with imaging techniques and non-culture based methods which include antigen-based assays, metabolite detection and molecular detection of fungal DNA from body fluid samples using conserved or specific genome sequences. The AGIHO presents recommendations for the diagnosis of invasive fungal infections with risk-adapted screening concepts for the neutropenic and febrile episodes of patients with hemato-oncological disorders.

Keywords

Fungal infections Diagnosis Neutropenia Cancer 

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • M. Ruhnke
    • 1
  • A. Böhme
    • 2
  • D. Buchheidt
    • 3
  • K. Donhuijsen
    • 4
  • H. Einsele
    • 5
  • R. Enzensberger
    • 6
  • A. Glasmacher
    • 7
  • H. Gümbel
    • 8
  • C.-P. Heussel
    • 9
  • M. Karthaus
    • 10
  • E. Lambrecht
    • 11
  • T. Südhoff
    • 12
  • H. Szelényi
    • 13
  1. 1.Dept. of Medicine, Div. Onkology/HematologyCharité Universitätsmedizin Berlin, Campus Charité MitteBerlinGermany
  2. 2.Dept. of Internal Medicine, Med. Clinic III, Hematology/Oncology/Infectious Diseases/Rheumatology J.W. Goethe UniversityFrankfurt/MainGermany
  3. 3.Dept. III. of Internal MedicineMannheim University Hospital, University of HeidelbergMannheimGermany
  4. 4.Institute of PathologyMunicipal Hospital of BraunschweigBraunschweigGermany
  5. 5.Dept. of Internal Medicine, Med. Clinic II, Hematology/Oncology/RheumatologyEberhard-Karls-UniversitätTübingenGermany
  6. 6.Institute of Medical MicrobiologyJ.W. Goethe UniversityFrankfurt/MainGermany
  7. 7.Dept. of Internal Medicine, Med. Clinic and Policlinic IUniversity HospitalBonnGermany
  8. 8.Dept. of OphthalmologyAcademic Bundeswehr-ClinicUlmGermany
  9. 9.Dept. of RadiologyJohannes Gutenberg-UniversityMainzGermany
  10. 10.Dept. of Internal Medicine, Med. Clinic IIEv. Johannes-KrankenhausBielefeld
  11. 11.Institute of PathologyJ.W. Goethe UniversityFrankfurt/MainGermany
  12. 12.Dept. of Internal MedicineRuhr-University Bochum, KnappschaftskrankenhausBochumGermany
  13. 13.Dept. of Internal Medicine, Hematology/Oncology/Transfusion MedicineCharité Universitätsmedizin Berlin, Campus Benjamin FranklinBerlinGermany