Annals of Hematology

, Volume 83, Issue 2, pp 124–126

Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)

Authors

  • B. Alpen
    • Department for Internal Medicine, Hematology, Oncology, ImmunologyHospital of the Philipps University
    • Department for RadiooncologyCharité Hospital of Humboldt University
  • T. Wündisch
    • Department for Internal Medicine, Hematology, Oncology, ImmunologyHospital of the Philipps University
  • J. Dierlamm
    • Department for Oncology and HematologyUniversity-Hospital Eppendorf
  • G. Börsch
    • Elisabeth Hospital
  • M. Stolte
    • Institute for PathologyHospital Bayreuth
    • Department for Internal Medicine, Hematology, Oncology, ImmunologyHospital of the Philipps University
Case Report

DOI: 10.1007/s00277-003-0763-5

Cite this article as:
Alpen, B., Wündisch, T., Dierlamm, J. et al. Ann Hematol (2004) 83: 124. doi:10.1007/s00277-003-0763-5

Abstract

To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.

Keywords

MALT IgH t(11;18)

Copyright information

© Springer-Verlag 2004