Annals of Hematology

, Volume 81, Issue 2, pp 111–114

Sweet's syndrome associated with retinoic acid syndrome in a patient with promyelocytic leukemia

  • L. Astudillo
  • F. Loche
  • W. Reynish
  • F. Rigal-Huguet
  • L. Lamant
  • J. Pris
Case Report

DOI: 10.1007/s00277-001-0416-5

Cite this article as:
Astudillo, L., Loche, F., Reynish, W. et al. Ann Hematol (2002) 81: 111. doi:10.1007/s00277-001-0416-5

Abstract.

We report a case of Sweet's syndrome associated with retinoic acid syndrome in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid (ATRA). Sweet's syndrome appeared on day 6 of ATRA therapy for promyelocytic leukemia. It was associated with a mild retinoic acid syndrome, an inflammatory syndrome occurring in 25% of patients treated with ATRA and characterized by features of capillary leakage with systemic inflammatory signs. The ATRA therapy was discontinued for 11 days and treatment with corticosteroids improved the systemic and cutaneous signs. Only 11 cases of Sweet's syndrome associated with ATRA have been previously reported in the literature, involving only the skin in eight cases, the skin and muscles in two cases, and the lung, kidney, fascia, and muscles in one case. Sweet's syndrome was followed by retinoic acid syndrome in one of these cases. The previously reported cases are reviewed, and the mechanisms of Sweet's and retinoic acid syndromes and the link between them are discussed.

Sweet's syndrome All-trans retinoic acid Promyelocytic leukemia Retinoic acid syndrome

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • L. Astudillo
    • 1
  • F. Loche
    • 3
  • W. Reynish
    • 4
  • F. Rigal-Huguet
    • 1
  • L. Lamant
    • 5
  • J. Pris
    • 1
  1. 1.Department of Haematology, University Hospital, Purpan, 1 place du Dr Baylac, 31059 Toulouse, FranceFrance
  2. 2.62 avenue de la Garonnette, 31000 Toulouse, FranceFrance
  3. 3.Department of Dermatology, University Hospital, Purpan, 1 place du Dr Baylac, 31059 Toulouse, FranceFrance
  4. 4.Department of Internal Medicine, University Hospital, Purpan, 1 place du Dr Baylac, 31059 Toulouse, FranceFrance
  5. 5.Department of Pathology, University Hospital, Purpan, 1 place du Dr Baylac, 31059 Toulouse, FranceFrance