CardioVascular and Interventional Radiology

, Volume 35, Issue 2, pp 383–390

Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation

  • Johann Jakob Wendler
  • Maciej Pech
  • Simon Blaschke
  • Markus Porsch
  • Andreas Janitzky
  • Matthias Ulrich
  • Oliver Dudeck
  • Jens Ricke
  • Uwe-Bernd Liehr
Laboratory Investigation

DOI: 10.1007/s00270-011-0187-x

Cite this article as:
Wendler, J.J., Pech, M., Blaschke, S. et al. Cardiovasc Intervent Radiol (2012) 35: 383. doi:10.1007/s00270-011-0187-x

Abstract

Purpose

The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE.

Methods

Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys.

Results

In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave.

Conclusion

The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.

Keywords

Nonthermal irreversible electroporationAngiographyIsolated perfused kidneyTissue ablationVascular protection

Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

Authors and Affiliations

  • Johann Jakob Wendler
    • 1
  • Maciej Pech
    • 2
  • Simon Blaschke
    • 1
  • Markus Porsch
    • 1
  • Andreas Janitzky
    • 1
  • Matthias Ulrich
    • 1
  • Oliver Dudeck
    • 2
  • Jens Ricke
    • 2
  • Uwe-Bernd Liehr
    • 1
  1. 1.Department of UrologyUniversity of MagdeburgMagdeburgGermany
  2. 2.Department of Radiology and Nuclear MedicineUniversity of MagdeburgMagdeburgGermany