Case Report

CardioVascular and Interventional Radiology

, Volume 34, Issue 2, pp 419-423

High Intensity Focused Ultrasound Ablation of Pancreatic Neuroendocrine Tumours: Report of Two Cases

  • Gianluigi OrgeraAffiliated withUnit of Interventional Radiology, European Institute of Oncology Email author 
  • , Miltiadis KrokidisAffiliated withDepartment of Radiology, St. Thomas` Hospital
  • , Lorenzo MonfardiniAffiliated withUnit of Interventional Radiology, European Institute of Oncology
  • , Guido BonomoAffiliated withUnit of Interventional Radiology, European Institute of Oncology
  • , Paolo Della VignaAffiliated withUnit of Interventional Radiology, European Institute of Oncology
  • , Nicola FazioAffiliated withDivision of Medical Oncology, European Institute of Oncology
  • , Franco OrsiAffiliated withUnit of Interventional Radiology, European Institute of Oncology

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Abstract

We describe the use of ultrasound-guided high-intensity focused ultrasound (HIFU) for ablation of two pancreatic neuroendocrine tumours (NETs; insulinomas) in two inoperable young female patients. Both suffered from episodes of severe nightly hypoglycemia that was not efficiently controlled by medical treatment. After HIFU ablation, local disease control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 9-month follow-up. The lesions appeared to be decreased in volume, and there was decreased enhancing pattern in the multidetector computed tomography control (MDCT). HIFU is likely to be a valid alternative for symptoms control in patients with pancreatic NETs. However, currently the procedure should be reserved for inoperable patients for whom symptoms cannot be controlled by medical therapy.

Keywords

Interventional Radiology Interventional Oncology