CardioVascular and Interventional Radiology

, Volume 33, Issue 3, pp 596–600

Small Intestinal Submucosa Plug for Closure of Dilated Nephrostomy Tracts: A Pilot Study in Swine

Authors

  • Hideyaki Kakizawa
    • Dotter Interventional InstituteOregon Health Sciences University
  • M. J. Conlin
    • Division of Urology, Department of SurgeryOregon Health Sciences University
    • Dotter Interventional InstituteOregon Health Sciences University
  • Barry T. Uchida
    • Dotter Interventional InstituteOregon Health Sciences University
  • Marc Loriaux
    • Department of PathologyOregon Health Sciences University
  • Young Hwan Kim
    • Dotter Interventional InstituteOregon Health Sciences University
  • Frederick S. Keller
    • Dotter Interventional InstituteOregon Health Sciences University
  • Josef Rösch
    • Dotter Interventional InstituteOregon Health Sciences University
Technical Note

DOI: 10.1007/s00270-010-9811-4

Cite this article as:
Kakizawa, H., Conlin, M.J., Pavcnik, D. et al. Cardiovasc Intervent Radiol (2010) 33: 596. doi:10.1007/s00270-010-9811-4

Abstract

The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.

Keywords

Biomaterial Small Intestinal submucosa Interventional procedures Embolization Kidneys

Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2010