Technical Note

CardioVascular and Interventional Radiology

, Volume 33, Issue 3, pp 596-600

Small Intestinal Submucosa Plug for Closure of Dilated Nephrostomy Tracts: A Pilot Study in Swine

  • Hideyaki KakizawaAffiliated withDotter Interventional Institute, Oregon Health Sciences University
  • , M. J. ConlinAffiliated withDivision of Urology, Department of Surgery, Oregon Health Sciences University
  • , Dusan PavcnikAffiliated withDotter Interventional Institute, Oregon Health Sciences University Email author 
  • , Barry T. UchidaAffiliated withDotter Interventional Institute, Oregon Health Sciences University
  • , Marc LoriauxAffiliated withDepartment of Pathology, Oregon Health Sciences University
  • , Young Hwan KimAffiliated withDotter Interventional Institute, Oregon Health Sciences University
  • , Frederick S. KellerAffiliated withDotter Interventional Institute, Oregon Health Sciences University
  • , Josef RöschAffiliated withDotter Interventional Institute, Oregon Health Sciences University

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Abstract

The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.

Keywords

Biomaterial Small Intestinal submucosa Interventional procedures Embolization Kidneys