CardioVascular and Interventional Radiology

, Volume 31, Issue 3, pp 468–476

Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results

  • Joachim Kettenbach
  • Alfred Stadler
  • Isabella v. Katzler
  • Rüdiger Schernthaner
  • Melanie Blum
  • Johannes Lammer
  • Thomas Rand
Review/State of the Art

DOI: 10.1007/s00270-007-9280-6

Cite this article as:
Kettenbach, J., Stadler, A., Katzler, I.v. et al. Cardiovasc Intervent Radiol (2008) 31: 468. doi:10.1007/s00270-007-9280-6

Abstract

Transarterial chemoembolization (TACE) involves the emulsification of a chemotherapeutic agent in a viscous drug carrier, delivered intra-arterially to liver tumor for maximum effect. TACE reduces arterial inflow, diminishes washout of the chemotherapeutic agent, and decreases systemic exposure. Despite evidence of some clinical success with TACE, a new type of microspheres with drug-eluting capabilities may offer a precisely controlled and sustainable release of the chemotherapeutic agent into the tumor bed. In animal trials tumor necrosis (approaching 100%) was greatest at 7 days, with significantly lower plasma concentrations of doxorubicin than in control animals treated with doxorubicin intra-arterially. Clinically, drug-eluting microspheres loaded with doxorubicin, either at 75 mg/m2 or at a fixed dose of 150 mg, were used recently and no severe disorders of the hepatic function were observed postprocedure, while a substantial reduction of the fetoprotein levels occurred. An interim analysis of the first 15 patients from the Hong Kong group at 3 months showed an objective response rate of 61.54% and 53.84% according to EASL criteria and RECIST criteria, respectively, and a survival rate of 93.3%. In this paper we present how to use microspheres loaded with doxorubicin and review their clinical value and preliminary performance for treatment of unresectable liver cancer.

Keywords

CarcinomaHepatocellularChemoembolizationTherapeuticLiverDoxorubicin microspheresEmbolic agentsDrug delivery

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Joachim Kettenbach
    • 1
  • Alfred Stadler
    • 1
  • Isabella v. Katzler
    • 1
  • Rüdiger Schernthaner
    • 1
  • Melanie Blum
    • 1
  • Johannes Lammer
    • 1
  • Thomas Rand
    • 1
  1. 1.Division of Angiography and Interventional Radiology, Department of RadiologyMedical University Vienna, General Hospital of ViennaViennaAustria