, Volume 30, Issue 4, pp 571-592
Date: 22 May 2007

Radioembolization with 90Y Microspheres: Angiographic and Technical Considerations

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The anatomy of the mesenteric system and the hepatic arterial bed has been demonstrated to have a high degree of variation. This is important when considering pre-surgical planning, catheterization, and trans-arterial hepatic therapies. Although anatomical variants have been well described, the characterization and understanding of regional hepatic perfusion in the context of radioembolization have not been studied with great depth. The purpose of this review is to provide a thorough discussion and detailed presentation of the angiographic and technical aspects of radioembolization. Normal vascular anatomy, commonly encountered variants, and factors involved in changes to regional perfusion in the presence of liver tumors are discussed. Furthermore, the principles described here apply to all liver-directed transarterial therapies.

R.S. and J.-F.G. are consultants for MDS Nordion. R.M., D.L., L.B., and J.I.B. are proctors for Sirtex Medical. A.S.K. has received honoraria from MDS Nordion and Sirtex Medical. This work was not funded.