CardioVascular and Interventional Radiology

, Volume 29, Issue 5, pp 811–818

Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success

  • Andrea Veltri
  • Amedeo Calvo
  • Irene Tosetti
  • Eva Pagano
  • Andrea Genovesio
  • Valentina Virzì
  • Ugo Ferrando
  • Dario Fontana
  • Giovanni Gandini
Article

DOI: 10.1007/s00270-005-0261-3

Cite this article as:
Veltri, A., Calvo, A., Tosetti, I. et al. Cardiovasc Intervent Radiol (2006) 29: 811. doi:10.1007/s00270-005-0261-3

Abstract

Purpose

Preliminary clinical studies have shown the feasibility, safety, and efficacy of radiofrequency thermal ablation (RFA) of renal tumors, but only a few have analyzed the prognostic factors for technical success and there are no long-term results. Our objective was to statistically evaluate our mid-term results of percutaneous US-guided RFA in order to define predictors for complications and technical success.

Methods

We selected for treatment 44 tumors in 31 patients (24 with renal cell carcinoma, 7 with hereditary tumors, 15 with a solitary kidney), up to 5 cm in diameter.

Results

Eight adverse events occurred; 3 (6.8%) were major complications, successfully treated with interventional radiology procedures in 2 cases. Exophytic extension of the tumor was protective against complications (p = 0.040). Technical success was obtained in 38 lesions after one RFA session and in 39 (89%) after one more session, when possible. At the end of treatment, central extension was the only negative predictor for technical success (p = 0.007), while neither size >3 cm (p = 0.091) nor other prognostic factors were statistically significant.

Conclusion

US-guided percutaneous RFA can be proposed for non-central renal tumors up to 5 cm, also in patients without surgical contraindications, thanks to a low incidence of complications and a high success rate. Randomized controlled trials versus surgery are now needed to investigate long-term comparative results.

Keywords

Interventional radiologyPercutaneous focal tissue ablationRadiofrequency ablationRenal cancerUS-guided therapeutic procedures

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Andrea Veltri
    • 1
  • Amedeo Calvo
    • 1
  • Irene Tosetti
    • 1
  • Eva Pagano
    • 2
  • Andrea Genovesio
    • 1
  • Valentina Virzì
    • 1
  • Ugo Ferrando
    • 3
  • Dario Fontana
    • 4
  • Giovanni Gandini
    • 1
  1. 1.Institute of Diagnostic and Interventional RadiologyUniversity of TurinTurinItaly
  2. 2.Unit of Cancer EpidemiologyUniversity of TurinTurinItaly
  3. 3.Unit of UrologySan Giovanni Battista HospitalTurinItaly
  4. 4.Institute of UrologyUniversity of TurinTurinItaly