World Journal of Surgery

, Volume 20, Issue 2, pp 168–172

Gastric Carcinoids and Neuroendocrine Carcinomas: Pathogenesis, Pathology, and Behavior

Authors

  • Guido Rindi
    • Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy
  • Cesare Bordi
    • Institute of Anatomic Pathology, University of Parma, Via Gramsci 14, 43100 Parma, Italy
  • Sigrid Rappel
    • Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany
  • Stefano La Rosa
    • Department of Pathology, University of Pavia at Varese, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
  • Manfred Stolte
    • Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany
  • Enrico Solcia
    • Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy

DOI: 10.1007/s002689900026

Cite this article as:
Rindi, G., Bordi, C., Rappel, S. et al. World J. Surg. (1996) 20: 168. doi:10.1007/s002689900026

Abstract. The goal of this study was to provide information of prognostic value for gastric endocrine tumors. A total of 205 gastric endocrine tumors have been studied: 193 well differentiated tumors [2 gastrin cell tumors, 191 enterochromaffin-like (ECL) cell tumors] and 12 poorly differentiated carcinomas. Subtyping of ECL cell tumors (carcinoids) resulted in 152 associated with chronic atrophic gastritis (CAG) (type 1); 12 associated with hypertrophic gastropathy (HG) due to Zollinger-Ellison syndrome with multiple endocrine neoplasia type I (type 2), and 27 with no specific association (type 3, sporadic). Type 1 cases occurred most often in female (108 of 152), elderly (mean 63 years) patients, with no tumor-related death at an overall mean follow-up of 53 months. The 12 type 2 cases were equally distributed between the sexes (six of each), with a mean age of 45 years; there was one tumor-related death (49 months after diagnosis) and an overall mean survival of 84 months. Type 3 cases were mostly in men (20 of 27), with a mean age of 55 years; there were seven tumor-related deaths at a mean follow-up of 28 months. Poorly differentiated neuroendocrine carcinomas were observed in elderly patients (mean 63 years, range 41–76 years) of both sexes, with nine tumor-related deaths and a mean survival of 7 months. It was concluded that correct clinicopathologic subtyping may predict the clinical behavior of gastric endocrine tumors.

Copyright information

© 1996 by the Société Internationale de Chir ugie