World Journal of Surgery

, Volume 24, Issue 11, pp 1377–1385

Iatrogenic Thyrotoxicosis: Causal Circumstances, Pathophysiology, and Principles of Treatment—Review of the Literature

Authors

  • Michel Meurisse
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
  • Laragh Gollogly
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
  • Cyrille Degauque
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
  • Isabelle Fumal
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
  • Thierry Defechereux
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
  • Etienne Hamoir
    • Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium
Article

DOI: 10.1007/s002680010228

Cite this article as:
Meurisse, M., Gollogly, L., Degauque, C. et al. World J. Surg. (2000) 24: 1377. doi:10.1007/s002680010228

Abstract

Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis may also result from a variety of conditions other than thyroid hyperfunction. The present report focuses on the etiologies, pathophysiology, and treatment of iatrogenic thyrotoxicosis. Iatrogenic thyrotoxicosis may be caused by (1) subacute thyroiditis (a result of lymphocytic infiltration, cellular injury, trauma, irradiation) with release of preformed hormones into circulation; (2) excessive ingestion of thyroid hormones (“thyrotoxicosis factitia”); (3) iodine-induced hyperthyroidism (radiologic contrast agents, topical antiseptics, other medications). Among these causes of iatrogenic thyrotoxicosis, that induced by the iodine overload and cytotoxicity associated with amiodarone represents a significant challenge. Successful management of amiodarone-induced thyrotoxicosis requires close cooperation between endocrinologists and endocrine surgeons. Surgical treatment may have a leading yet often underestimated role in view of the potential life-threatening severity of this disease, whereas others kinds of iatrogenic thyrotoxicosis are usually treated conservatively.

Copyright information

© Société Internationale de Chirurgie 2000