, Volume 37, Issue 2, p 478
Date: 08 Nov 2012

Incidence and Risk Factors of the Intraoperative Localization Failure of Nonpalpable Breast Lesions by Radio-Guided Occult Lesion Localization: A Retrospective Analysis of 579 Cases: Reply

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We are pleased about your interest in our article that focused on the difficulty of detecting nonpalpable breast lesions [1, 2]. The failure of intraoperative detection of these lesions by radio-guided lesion localization (ROLL) or by wire hook is an important topic because they represent the majority of breast lesions.

It should be mandatory that intraoperative radiological examination be performed on every surgical specimen obtained by breast-conserving surgery, whether obtained by mammography (in the most cases) or by ultrasonography in cases of negative preoperative mammography. In fact, radiological evaluation of surgical resection margins, especially in the absence of subsequent, intraoperative frozen section examination, could ensure correct targeting of the lesion and could identify the size of the margins needed to remove all of the tumor.

We agree that injecting contrast medium together with the radiotracer can be helpful for the radiologist. It probably improves both preoperat