World Journal of Surgery

, Volume 36, Issue 5, pp 1189–1194

Cancer Stem Cell Marker Bmi-1 Expression is Associated with Basal-like Phenotype and Poor Survival in Breast Cancer

  • Yanyang Wang
  • Hong Zhe
  • Zhe Ding
  • Ping Gao
  • Ningmei Zhang
  • Guofu Li
Article

DOI: 10.1007/s00268-012-1514-3

Cite this article as:
Wang, Y., Zhe, H., Ding, Z. et al. World J Surg (2012) 36: 1189. doi:10.1007/s00268-012-1514-3

Abstract

Background

The purpose of present study was to examine the expression of cancer stem cell marker Bmi-1 in breast cancer tissue and to evaluate the clinical implication of Bmi-1 expression for these patients.

Methods

A total of 171 breast cancer patients who received surgical treatment in our hospital were enrolled in this study. Bmi-1 expression in breast cancer tissue was assayed by immunohistochemistry. Statistical analyses were applied to test the relationship between expression of Bmi-1 and clinicopathologic features and patient survival. The relationship between Bmi-1 and the basal-like phenotype of breast cancer also was analyzed in this study.

Results

Positive Bmi-1 expression was detected in 89 of 171 (52%) invasive breast cancers patients. The Bmi-1 status was significantly correlated to histological grade III (p = 0.001) and basal-like phenotype (p < 0.001). The 5 year overall survival of the patients with Bmi-1-positive and -negative cancers were 78 and 91.9%, respectively (p = 0.03). Histological grade (p = 0.046) and Bmi-1 status (p = 0.012) were detected as the independent prognostic factors in the Cox regression test.

Conclusions

Bmi-1 status is an independent prognostic factor, which also is associated with tumor histological grade and basal-like phenotype. The high proportions of positive Bmi-1 expression in basal-like breast cancer may be related to the high aggressiveness behavior of this subtype of breast cancer.

Copyright information

© Société Internationale de Chirurgie 2012

Authors and Affiliations

  • Yanyang Wang
    • 1
  • Hong Zhe
    • 1
  • Zhe Ding
    • 1
  • Ping Gao
    • 2
  • Ningmei Zhang
    • 3
  • Guofu Li
    • 3
  1. 1.Department of Radiation OncologyGeneral Hospital of Ningxia Medical UniversityYinchuanChina
  2. 2.Department of Surgical OncologyGeneral Hospital of Ningxia Medical UniversityYinchuanChina
  3. 3.Department of PathologyGeneral Hospital of Ningxia Medical UniversityYinchuanChina

Personalised recommendations