World Journal of Surgery

, Volume 35, Issue 8, pp 1693–1699

Overview of the Development of Personalized Genomic Medicine and Surgery

  • F. Charles Brunicardi
  • Richard A. Gibbs
  • David A. Wheeler
  • John Nemunaitis
  • William Fisher
  • John Goss
  • Changyi Chen
Article

DOI: 10.1007/s00268-011-1056-0

Cite this article as:
Brunicardi, F.C., Gibbs, R.A., Wheeler, D.A. et al. World J Surg (2011) 35: 1693. doi:10.1007/s00268-011-1056-0

Abstract

Personalized genomic medicine and surgery (PGMS) represents a new approach to health care that customizes patients’ medical treatment according to their own genetic information. This new approach is the result of increased knowledge of the human genome and ways this information can be applied by physicians in the medical and surgical management of their patients. A patient’s genotype can yield important information concerning disease susceptibility and the effectiveness of medications, therefore guiding specific, targeted imaging and treatment therapies. This review summarizes major achievements of human genomic studies and applications of genomics in health care. Five years ago we developed a model for the development of PGMS in which genomic profile guides choice of therapy. In this article we discussed our progress, including an updating of the model, and a future vision of PGMS.

Copyright information

© Société Internationale de Chirurgie 2011

Authors and Affiliations

  • F. Charles Brunicardi
    • 1
  • Richard A. Gibbs
    • 2
  • David A. Wheeler
    • 2
  • John Nemunaitis
    • 3
  • William Fisher
    • 1
  • John Goss
    • 1
  • Changyi Chen
    • 1
  1. 1.Michael E. DeBakey Department of SurgeryBaylor College of MedicineHoustonUSA
  2. 2.Human Genome Sequencing Center, Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA
  3. 3.Mary Crowley Cancer Research CenterDallasUSA