World Journal of Surgery

, Volume 35, Issue 8, pp 1732–1737

A Primer on a Hepatocellular Carcinoma Bioresource Bank Using the Cancer Genome Atlas Guidelines: Practical Issues and Pitfalls

  • N. Thao T. Nguyen
  • Ron T. Cotton
  • Theresa R. Harring
  • Jacfranz J. Guiteau
  • Marie-Claude Gingras
  • David A. Wheeler
  • Christine A. O’Mahony
  • Richard A. Gibbs
  • F. Charles Brunicardi
  • John A. Goss
Article

DOI: 10.1007/s00268-010-0953-y

Cite this article as:
Nguyen, N.T.T., Cotton, R.T., Harring, T.R. et al. World J Surg (2011) 35: 1732. doi:10.1007/s00268-010-0953-y
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Abstract

Background

Since the advent of the human genome, the era of personalized genomic medicine is indisputably in progress.

Methods

In an effort to contribute to the evolving knowledge of genomic medicine, we have aimed directly at building a bioresource bank for hepatocellular carcinoma. This tumor bank is based on the rigorous guidelines set forth by the National Cancer Institute, and it offers analytes to help elucidate the mechanisms of progression from cirrhosis to malignancy, risk factors for recurrence, and applicability of current treatment options to a diverse group of people.

Conclusions

Surgeons have a privileged position between patients (and their cancer) and the benches of basic science. Thus, we offer a primer based on our own experiences, from which surgeons may take elements to build their own bioresource bank for use in collaboration with others. We highlight some practicalities and pitfalls that could be overlooked, as well as a discussion of possible solutions.

Copyright information

© Société Internationale de Chirurgie 2011

Authors and Affiliations

  • N. Thao T. Nguyen
    • 1
  • Ron T. Cotton
    • 1
  • Theresa R. Harring
    • 1
  • Jacfranz J. Guiteau
    • 1
  • Marie-Claude Gingras
    • 2
  • David A. Wheeler
    • 2
  • Christine A. O’Mahony
    • 1
    • 3
  • Richard A. Gibbs
    • 2
  • F. Charles Brunicardi
    • 1
  • John A. Goss
    • 1
    • 3
  1. 1.Michael E. DeBakey Department of SurgeryBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular and Human Genetics, Human Genome Sequencing CenterBaylor College of MedicineHoustonUSA
  3. 3.The Liver Center, Division of Abdominal Transplantation & Hepatobiliary Surgery, Michael E. DeBakey Department of SurgeryBaylor College of MedicineHoustonUSA

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