World Journal of Surgery

, Volume 34, Issue 8, pp 1908–1915

Analysis of 5-Year Survivors After a Macroscopic Curative Pancreatectomy for Invasive Ductal Adenocarcinoma

  • Kazuaki Shimada
  • Yoshihiro Sakamoto
  • Satoshi Nara
  • Minoru Esaki
  • Tomoo Kosuge
  • Nobuyoshi Hiraoka
Article

DOI: 10.1007/s00268-010-0570-9

Cite this article as:
Shimada, K., Sakamoto, Y., Nara, S. et al. World J Surg (2010) 34: 1908. doi:10.1007/s00268-010-0570-9

Abstract

Background

Surgical resections for invasive ductal adenocarcinoma of the pancreas can provide the only chance of cure, although the 5-year survivors are not always equated with cure.

Methods

A total of 229 who underwent a macroscopic curative pancreatectomy for invasive ductal adenocarcinoma between 1990 and 2003 and have been observed for more than 5 years from the time of resection were retrospectively analyzed. The data of patients who survived more than 5 years were compared with those died within 5 years. The recurrence pattern and factors that influenced an additional 5-year survival in the 5-year survivors were investigated.

Results

Forty patients (17%) survived more than 5 years, and the survival rate for an additional 5 years after surviving 5 years was 72%. A multivariate Cox hazards analysis showed that negative surgical margins status, less frequency of lymphatic invasion, stage ≤ IIB, and negative lymph node involvement were independent factors associated with long-term survival. Thirty patients (75%) were alive without recurrence, and eight (20%) died of disease within 7.3 years. Intrapancreatic nerve invasion was a significant factor predicting additional long-term survival in the 40 5-year survivors.

Conclusions

Limited cancer extension with negative lymph node metastases significantly contributes to the chance of surviving more than 5 years. A low incidence of intrapancreatic nerve invasion in the 5-year survivors affects the subsequent favorable survival.

Copyright information

© Société Internationale de Chirurgie 2010

Authors and Affiliations

  • Kazuaki Shimada
    • 1
  • Yoshihiro Sakamoto
    • 1
  • Satoshi Nara
    • 1
  • Minoru Esaki
    • 1
  • Tomoo Kosuge
    • 1
  • Nobuyoshi Hiraoka
    • 2
  1. 1.Hepatobiliary and Pancreatic Surgery DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Pathology DivisionNational Cancer Center Research InstituteTokyoJapan