, Volume 33, Issue 5, pp 1103-1104
Date: 03 Jan 2009

Effectiveness of Radiofrequency Ablation of Hepatocellular Carcinoma

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We read with interest the article by Rodriguez-Sanjuan et al., “Radiological and pathological assessment of hepatocellular carcinoma (HCC) response to radiofrequency ablation. A study on removed liver after transplantation” [1]. Among 30 hepatocellular carcinoma (HCC) nodules ranging between 1.5 and 6.0 cm in diameter, the authors found that pathologic response was complete in 14 nodules (46.7%) and incomplete in 16 nodules (53.3%), and that there was no significant relationship between complete necrosis and tumor diameter. In fact, the mean diameter in cases with complete and partial necrosis was 2.86 and 3.28 cm, respectively (p not significant). Furthermore, according to the data reported in their Table 1, complete necrosis was found in 8/16 (50%) tumors up to 3 cm large, in 6/14 (43%) between 3.1 and 6.0 cm, and in 4/6 (66.7%) smaller than 2 cm [1]. These results are quite surprising considering that in tumors up to 3 cm large submitted to radiofrequency ablation (RFA) as a bridge ...