World Journal of Surgery

, Volume 32, Issue 8, pp 1731–1737

Thrombosis Confined to the Portal Vein Is Not a Contraindication for Living Donor Liver Transplantation

  • Jai Young Cho
  • Kyung-Suk Suh
  • Woo Young Shin
  • Hae Won Lee
  • Nam-Joon Yi
  • Kuhn Uk Lee
Article

DOI: 10.1007/s00268-008-9651-4

Cite this article as:
Cho, J.Y., Suh, K., Shin, W.Y. et al. World J Surg (2008) 32: 1731. doi:10.1007/s00268-008-9651-4

Abstract

Background

There is a lack of agreement regarding preexisting portal vein thrombosis (PVT) in patients undergoing living donor liver transplantation (LDLT). We report the results of a single-center study to determine the impact of PVT on outcomes of adult LDLT recipients.

Methods

Of 133 cases of adult LDLT performed between January 2000 and December 2004, a thrombectomy was performed on 22 patients (16.5%) with PVT during the transplant procedure. One hundred eleven patients without PVT (group 1) were compared with those with a thrombosis confined to the portal vein (group 2; n = 15) and patients with the thrombosis beyond the portal vein (group 3; n = 7).

Results

The sensitivities of Doppler ultrasound and CT in detecting PVT were 50 and 63.6%. A prior history of variceal bleeding (OR = 10.6, p = 0.002) and surgical shunt surgery (OR = 28.1, p = 0.044) were found to be an independent risk factors for PVT. The rate of postoperative PVT was significantly higher in patients with PVT than in those without (18.2 vs. 2.7%; p = 0.014). In particular, the rethrombosis rate in group 3 was 28.6%. The actuarial 3-year patient survival rate in PVT patients (73.6%) was similar to that of the non-PVT patients (85.3%; p = 0.351). However, the actuarial 3-year patient survival rate in group 3 was 38.1%, which was significantly lower than that in groups 1 and 2 (p = 0.006).

Conclusion

A thrombosis confined to the portal vein per se should not be considered a contraindication for LDLT.

Copyright information

© Société Internationale de Chirurgie 2008

Authors and Affiliations

  • Jai Young Cho
    • 1
  • Kyung-Suk Suh
    • 1
  • Woo Young Shin
    • 1
  • Hae Won Lee
    • 1
  • Nam-Joon Yi
    • 1
  • Kuhn Uk Lee
    • 1
  1. 1.Department of SurgerySeoul National University College of Medicine, Seoul National University HospitalChongno-gu, SeoulKorea