Does Familial Non-Medullary Thyroid Cancer Adversely Affect Survival?
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Familial non-medullary thyroid cancer (FNMTC) is associated with a higher rate of multifocality and a higher recurrence rate than sporadic thyroid cancer. However, the effect of FNMTC on life expectancy is unknown.
Material and Methods
Using data from our FNMTC database, we calculated life expectancy and survival rates after diagnosis of FNMTC and compared the results with the rates for unaffected family members and for the standard US population. Overall life expectancy and survival rates were calculated using the Kaplan–Meier method. We compared patients from families with 2 affected members with patients from families with ≥3 affected members. We also compared patients diagnosed in a known familial setting (index cases and subsequent cases) with patients diagnosed before the familial setting was recognized.
There were 139 affected patients with 757 unaffected family members. The mean age at diagnosis was 40.8 ± 13.9 years and the mean follow-up time was 9.4 ± 11.7 years. Ten patients died of thyroid cancer during follow-up. The life expectancy of patients with FNMTC was similar to that of their unaffected family members. Survival was significantly shorter for patients with 3 or more affected family members, for patients diagnosed before the familial setting was recognized, and for patients with anaplastic cancer.
Our results suggest that FNMTC may be more aggressive than sporadic thyroid cancer, particularly in families with 3 or more affected members. However, when recognized and treated appropriately, it does not significantly shorten the overall life expectancy of the affected patients.
- Hemminki, K, Li, X (2003) Familial risk of cancer by site and histopathology. Int J Cancer 103: pp. 105-109 CrossRef
- Goldgar, DE, Easton, DF, Cannon-Albright, LA, Skolnick, MH (1994) Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 86: pp. 1600-1608
- Pal, T, Vogl, FD, Chappuis, PO (2001) Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study. J Clin Endocrinol Metab 86: pp. 5307-5312 CrossRef
- Hemminki, K, Eng, C, Chen, B (2005) Familial risks for nonmedullary thyroid cancer. J Clin Endocrinol 90: pp. 5747-5753 CrossRef
- Brunaud, L, Zarnegar, R, Wada, N (2003) Chromosomal aberrations by comparative genomic hybridization in thyroid tumors in patients with familial nonmedullary thyroid cancer. Thyroid 13: pp. 621-629 CrossRef
- Sturgeon, C, Clark, OH (2005) Familial nonmedullary thyroid cancer. Thyroid 15: pp. 588-593 CrossRef
- Alsanea, O, Clark, OH (2001) Familial thyroid cancer. Curr Opin Oncol 13: pp. 44-51 CrossRef
- Charkes, ND (1998) On the prevalence of familial nonmedullary thyroid cancer. Thyroid 8: pp. 857-858
- Uchino, S, Noguchi, S, Kawamoto, H (2002) Familial nonmedullary thyroid carcinoma characterized by multifocality and a high recurrence rate in a large study population. World J Surg 26: pp. 897-902 CrossRef
- Grossman, RF, Tu, SH, Duh, QY (1995) Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment. Arch Surg 130: pp. 892-897
- Takami, H, Ozaki, O, Ito, K (1996) Familial nonmedullary thyroid cancer: an emerging entity that warrants aggressive treatment. Arch Surg 131: pp. 676
- Lupoli, G, Vitale, G, Caraglia, M (1999) Familial papillary thyroid microcarcinoma: a new clinical entity. Lancet 353: pp. 637-639 CrossRef
- Alsanea, O, Wada, N, Ain, K (2000) Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series. Surgery 128: pp. 1043-1050 CrossRef
- Loh, KC, Lo, JC, Greenspan, FS (1997) Familial papillary thyroid cancer: a case report. Ann Acad Med Singapore 26: pp. 503-506
- Arias, E (2004) United States life tables, 2002. Ntl Vital Stat Rep 53: pp. 1-38
- Schlumberger, MJ (1998) Papillary and follicular thyroid carcinoma. N Engl J Med 338: pp. 297-306 CrossRef
- Sherman, SI (2003) Thyroid carcinoma. Lancet 361: pp. 501-511 CrossRef
- Wu, HS, Young, MT, Ituarte, PH (2000) Death from thyroid cancer of follicular cell origin. J Am Coll Surg 191: pp. 600-606 CrossRef
- Links, TP, Tol, KM, Jager, PL (2005) Life expectancy in differentiated thyroid cancer: a novel approach to survival analysis. Endocr Relat Cancer 12: pp. 273-280 CrossRef
- Uchino, S, Noguchi, S, Yamashita, H (2004) Detection of asymptomatic differentiated thyroid carcinoma by neck ultrasonographic screening for familial nonmedullary thyroid carcinoma. World J Surg 28: pp. 1099-1102 CrossRef
- Maxwell, EL, Hall, FT, Freeman, JL (2004) Familial non-medullary thyroid cancer: a matched-case control study. Laryngoscope 114: pp. 2182-2186 CrossRef
- Vriens, MR, Sabanci, U, Epstein, HD (1999) Reliability of fine-needle aspiration in patients with familial nonmedullary thyroid cancer. Thyroid 9: pp. 1011-1016 CrossRef
- Does Familial Non-Medullary Thyroid Cancer Adversely Affect Survival?
World Journal of Surgery
Volume 30, Issue 5 , pp 787-793
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors
- Author Affiliations
- 2. Advanced Research Technologies, Applied Biosystems, 850 Lincoln Center Drive, MS 447, Foster City, CA, 94404-1105, USA
- 4. Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, Geneva 14, 1211, Switzerland
- 1. Endocrine Surgical Oncology, UCSF / Mount Zion Medical Center, San Francisco, CA, 94143-1674, USA
- 3. Epidemiology and Biostatistics, UCSF, San Francisco, CA, 94143-0560, USA