World Journal of Surgery

, Volume 28, Issue 3, pp 301–306

Nitric Oxide and Wound Healing

World Progress in Surgery

DOI: 10.1007/s00268-003-7396-7

Cite this article as:
Rizk, M., Witte, M. & Barbul, A. World J. Surg. (2004) 28: 301. doi:10.1007/s00268-003-7396-7


Nitric oxide is a short-lived free radical that acts at the molecular, cellular, and physiologic level. Since its discovery almost 20 years ago it has proven itself as an important element in wound healing. This review highlights many of the important aspects of nitric oxide in wound healing, including a review of the basic biology of nitric oxide, its role as part of the cytokine cascade and as a promoter of angiogenesis, as well as its more recently elucidated role in apoptosis.

Copyright information

© Société Internationale de Chirurgie 2004

Authors and Affiliations

  1. 1.Department of Surgery, Sinai Hospital of BaltimoreJohns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Eberhard-Karls-UniversitaetTuebingenGermany