, Volume 37, Issue 5, pp 1010-1011
Date: 14 Aug 2013

Pre- and/or Postsurgical Administration of Estradiol Benzoate Increases Rates of Skin Flap Viability in Female Rats

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Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

This interesting paper discusses the protective effects that intramuscular injections of estrogen have on flap survival. The authors should be complimented for their endeavor and their contribution to ideas for potential improvements in outcomes of flap surgery.

Using an ovariectomy model in female rats, the authors studied the protective effect that intramuscular injection of estradiol has on a random flap. Estrogen therapy was initiated either 3 days before flap surgery or on the day of surgery. The area of flap necrosis was measured and compared between the experimental and control groups.

Earlier studies have demonstrated that estrogen positively alters flap necrosis [1] and that physiologic levels of estrogen (30–60 pg/ml) i ...