Aesthetic Plastic Surgery

, Volume 33, Issue 3, pp 409–412

Treatment of Hypertrophic Scars With Intralesional Botulinum Toxin Type A Injections: A Preliminary Report


    • Department of Plastic SurgerySecond Affiliated Hospital of Harbin Medical University
  • Fengmin Zhang
    • Department of Microbiology, College of Basic Medical ScienceHarbin Medical University
  • Ziwei Cui
    • Department of Plastic SurgeryDaqing Oil Hospital
Original Article

DOI: 10.1007/s00266-009-9334-z

Cite this article as:
Xiao, Z., Zhang, F. & Cui, Z. Aesth Plast Surg (2009) 33: 409. doi:10.1007/s00266-009-9334-z



Hypertrophic scar is the abnormal appearance of wound healing that usually causes major physical, psychological, and cosmetic problems. Treatment of the hypertrophic scar still is a dilemma due to the lack of effective and excellent methods and agents. Recent reports show that botulinum toxin type A (BTX-A) improves wound healing. Therefore, the authors hypothesized that BTX-A may be favorable for the improvement of hypertrophic scars.


A total of 19 patients were randomly assigned to a prospective clinical study. At 1-month intervals, BTX-A (2.5 U per cubic centimeter of lesion) was injected in these patients for a total of 3 months. All the patients were followed up for at least half a year. Therapeutic satisfaction was recorded, and the lesions were assessed for erythema, itching sensation, and pliability.


The study was completed by 19 patients. At the half-year follow-up visits, all the patients showed acceptable improvement, and the rate of therapeutic satisfaction was very high. The erythema score, itching sensation score, and pliability score after the BTX-A injection all were significantly lower than before the BTX-A injection. The differences all were statistically significant (P < 0.01).


For the treatment of hypertrophic scars, doctors and patients both found BTX-A acceptable because of its better therapeutic results. Its effect of eliminating or decreasing hypertrophic scars was promising.


Botulinum toxin type A Hypertrophic scar Treatment

Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2009