Aesthetic Plastic Surgery

, Volume 29, Issue 6, pp 472–478

Changing the Metabolic Profile by Large-Volume Liposuction: A Clinical Study Conducted with 123 Obese Women

  • Francesco D’Andrea
  • Roberto Grella
  • Maria Rosaria Rizzo
  • Elisa Grella
  • Rodolfo Grella
  • Gianfranco Nicoletti
  • Michelangela Barbieri
  • Giuseppe Paolisso
Article

DOI: 10.1007/s00266-005-0089-x

Cite this article as:
D’Andrea, F., Grella, R., Rizzo, M.R. et al. Aesth Plast Surg (2005) 29: 472. doi:10.1007/s00266-005-0089-x

Abstract

Adipose tissue is a metabolically active tissue. The hypertrophic fat cells of obese patients produce increased quantities of leptin and tumor necrosis factor-α (TNF-α) and are less sensitive to insulin. This study aimed to determine whether aspirating large amounts of these subcutaneous fat cells by large-volume liposuction (LVL), could change the metabolic profile in 123 obese women. All the patients had a main central body fat distribution (waist–hip ratio, 0.91±0.01) and a body mass index of 32.8 ± 0.8 kg/m). They were studied for 90 days after LVL to determine their changes in insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. During 3 months of follow-up evaluation, LVL resulted in a significantly improved insulin sensitivity, resting metabolic rate, serum adipocytokines, and inflammatory marker levels. Such parameters correlate with a decrease in fat mass and waist–hip ratio. Interestingly, no significant changes were seen between the first (21 days) and second (90 days) metabolic determinations after LVL. However, these findings, confirm other preliminary data published previously, and could change the actual role of LVL in the multidisciplinary treatment of obesity.

Keywords

AdipocytokinesHypertrophic fat cells Inflammatory stateInsulin resistanceLarge-volume liposuctionLeptinObesityRMR

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Francesco D’Andrea
    • 1
  • Roberto Grella
    • 1
  • Maria Rosaria Rizzo
    • 2
  • Elisa Grella
    • 1
  • Rodolfo Grella
    • 2
  • Gianfranco Nicoletti
    • 1
  • Michelangela Barbieri
    • 2
  • Giuseppe Paolisso
    • 2
  1. 1.Department of Plastic and Reconstructive SurgerySecond University of NaplesNaplesItaly
  2. 2.Department of Geriatric Medicine and Metabolic DiseaseSecond University of NaplesNaplesItaly