Cancer Immunology, Immunotherapy

, Volume 62, Issue 7, pp 1137–1148

Immune-suppressive properties of the tumor microenvironment

Authors

    • Department of General DermatologyMedical University of Graz
  • Mads Hald Andersen
    • Department of Hematology, Center for Cancer Immune Therapy (CCIT)University Hospital Herlev
  • David Schrama
    • Department of General DermatologyMedical University of Graz
  • Per thor Straten
    • Department of Hematology, Center for Cancer Immune Therapy (CCIT)University Hospital Herlev
Review

DOI: 10.1007/s00262-013-1434-6

Cite this article as:
Becker, J.C., Andersen, M.H., Schrama, D. et al. Cancer Immunol Immunother (2013) 62: 1137. doi:10.1007/s00262-013-1434-6

Abstract

Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. Here, we will focus on immune-modulating capacities of the tumor microenvironment.

Keywords

A disintegrin and metalloproteinase (ADAM)Indoleamine-2,3-dioxygenase (IDO)ArginaseHypoxiaAdenosineNatural killer group 2 member D (NKG2D) ligands

Copyright information

© Springer-Verlag Berlin Heidelberg 2013