Focussed Research Review

Cancer Immunology, Immunotherapy

, Volume 61, Issue 8, pp 1327-1341

First online:

The expression, function, and clinical relevance of B7 family members in cancer

  • Barbara SeligerAffiliated withInstitute of Medical Immunology, Martin Luther University Halle-Wittenberg Email author 
  • , Dagmar QuandtAffiliated withInstitute of Medical Immunology, Martin Luther University Halle-WittenbergSection of Rheumatology, Institute for Gastroenterology and Rheumatology, University of Leipzig

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The modulation and suppression of anti-tumor immune responses is a characteristic feature of tumor cells to escape immune surveillance. Members of the B7 family are involved in this process, since the level of activation of the anti-tumor immune response depends on the balance between co-stimulatory and co-inhibitory signals. Some molecules are often overexpressed in tumors, which has been associated with the pathogenesis and progression of malignancies as well as their immunological and non-immunological functions. The B7 homologs play a key role in the maintenance of self-tolerance and the regulation of both innate and adaptive immunity in tumor-bearing hosts. Furthermore, the blockade of negative signals mediated by the interaction of co-inhibitory ligands and counter-receptors of the B7 family is currently being studied as a potential immunotherapeutic strategy for the treatment of cancer in humans.


Cancer Co-stimulation B7 family PIVAC11 Therapy