Review

Cancer Immunology, Immunotherapy

, Volume 61, Issue 6, pp 751-759

Tumor microenvironment and lymphocyte infiltration

  • Gwendoline RahirAffiliated withLaboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles
  • , Muriel MoserAffiliated withLaboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles Email author 

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Abstract

There is ample evidence that the presence of tumor-infiltrating T lymphocytes is associated with a favorable prognostic in patients. These observations suggest that a limiting step to immune resistance and immunotherapy could be the capacity of tumor-specific T cells to reach tumor bed. In this article, we review some factors that may influence this infiltration, and in particular the nature of the vasculature, the expression of chemokines or tumor antigens and the presence of dendritic cells and CD4+ T lymphocytes.

Keywords

Tumor microenvironment Tumor-infiltrating lymphocytes (TIL) Vasculature Chemokines