Cancer Immunology, Immunotherapy

, Volume 61, Issue 4, pp 453–468

Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy

Review

DOI: 10.1007/s00262-012-1216-6

Cite this article as:
Rigamonti, N. & Bellone, M. Cancer Immunol Immunother (2012) 61: 453. doi:10.1007/s00262-012-1216-6

Abstract

The recent FDA approval of the first therapeutic vaccine against prostate cancer has revitalized the public interest in the fields of cancer immunology and immunotherapy. Yet, clinical results are modest. A reason for this limited success may reside in the capacity of the tumor to convert inflammation in a tumor-promoting condition and eventually escape immune surveillance. Here we present the main known interactions between the prostate tumor and the immune system, showing how the malignancy can dodge the immune system by also exerting several immunosuppressive mechanisms. We also discuss experimental and clinical strategies proposed to counteract cancer immune evasion and emphasize the importance of implementing appropriate murine models like the transgenic adenocarcinoma of the mouse prostate model for investigating the biology of prostate cancer and novel immunotherapy approaches against it.

Keywords

Immunotherapy Prostate cancer Mouse model Tumor immunity Immunosuppression 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Cellular Immunology Unit, Program of Immunology, Gene Therapy and Bio-Immunotherapy of Cancer (PIBIC)San Raffaele Scientific InstituteMilanItaly

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