Cancer Immunology, Immunotherapy

, Volume 61, Issue 9, pp 1521–1525

How to connect an IgE-driven response with CTL activity?

  • Barbara Platzer
  • Eleonora Dehlink
  • Shannon J. Turley
  • Edda Fiebiger
Symposium-in-writing paper

DOI: 10.1007/s00262-011-1127-y

Cite this article as:
Platzer, B., Dehlink, E., Turley, S.J. et al. Cancer Immunol Immunother (2012) 61: 1521. doi:10.1007/s00262-011-1127-y

Abstract

One of the goals of cell-based immune therapy in cancer is the induction of tumor-specific cytotoxic T-lymphocyte (CTL) responses. To achieve this objective, the ability of dendritic cells (DC) to cross-present tumor antigens can be exploited. One of the most efficient pathways for the induction of CTLs by cross-presentation is mediated by immunoglobulins of the IgG class, which are used by DCs to sample antigen in the form of immune complexes via Fc-gamma receptors. Could DCs use an IgE-mediated cross-presentation mechanism in a comparable manner to induce CTLs? We here discuss the potential of two human IgE Fc receptors, FcεRI and FcεRII, to serve as antigen uptake receptors for IgE-mediated cross-presentation. We conclude that the existence of an IgE-mediated cross-presentation pathway would provide a direct link between IgE-driven immune responses and CTL activity.

Keywords

AllergoOncology Dendritic cells Antigen presentation Fc receptors FcεRI CD23 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Barbara Platzer
    • 1
    • 2
  • Eleonora Dehlink
    • 3
  • Shannon J. Turley
    • 4
    • 5
  • Edda Fiebiger
    • 1
    • 2
  1. 1.Division of Gastroenterology and NutritionChildren’s Hospital BostonBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA
  3. 3.Department of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and EndocrinologyMedical University of ViennaViennaAustria
  4. 4.Department of Cancer Immunology and AIDSDana-Farber Cancer InstituteBostonUSA
  5. 5.Department of Microbiology and ImmunobiologyHarvard Medical SchoolBostonUSA

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