Review

Cancer Immunology, Immunotherapy

, 60:1509

First online:

Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma

  • Adam J. BogradAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer CenterCenter for Cell Engineering, Memorial Sloan-Kettering Cancer Center
  • , Kei SuzukiAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center
  • , Eva VertesAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer CenterCenter for Cell Engineering, Memorial Sloan-Kettering Cancer Center
  • , Christos ColovosAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer CenterCenter for Cell Engineering, Memorial Sloan-Kettering Cancer Center
  • , Eduardo A. MoralesAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center
  • , Michel SadelainAffiliated withCenter for Cell Engineering, Memorial Sloan-Kettering Cancer Center
  • , Prasad S. AdusumilliAffiliated withDivision of Thoracic Surgery, Memorial Sloan-Kettering Cancer CenterCenter for Cell Engineering, Memorial Sloan-Kettering Cancer Center Email author 

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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive, primary pleural malignancy with poor prognosis, hypothesized to originate from a chronic inflammatory state within the pleura. Similar to what has been observed in other solid tumors (melanoma, ovarian and colorectal cancer), clinical and pre-clinical MPM investigations have correlated anti-tumor immune responses with improved survival. As such, a better understanding of the complex MPM tumor microenvironment is imperative in strategizing successful immunotherapies. Herein, we review the immune responses vital to the development and progression of MPM, as well as assess the role of immunomodulatory therapies, highlighting recent pre-clinical and clinical immunotherapy investigations.

Keywords

Mesothelioma Immune response to cancer Immunotherapy Immunomodulation Tumor antigens