Cancer Immunology, Immunotherapy

, Volume 59, Issue 5, pp 675–686

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

  • Akio Yamasaki
  • Chizu Kameda
  • Rui Xu
  • Haruo Tanaka
  • Takehiko Tasaka
  • Nobuhito Chikazawa
  • Hiroyuki Suzuki
  • Takashi Morisaki
  • Makoto Kubo
  • Hideya Onishi
  • Masao Tanaka
  • Mitsuo Katano
Original Article

DOI: 10.1007/s00262-009-0783-7

Cite this article as:
Yamasaki, A., Kameda, C., Xu, R. et al. Cancer Immunol Immunother (2010) 59: 675. doi:10.1007/s00262-009-0783-7
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Abstract

Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammation-stimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.

Keywords

NF-κB Hh pathway Monocytes Pancreatic cancer 

Abbreviations

PBMCs

Peripheral blood mononuclear cells

Shh

Sonic hedgehog

PDAC

Pancreatic ductal adenocarcinomas

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Akio Yamasaki
    • 1
  • Chizu Kameda
    • 1
  • Rui Xu
    • 1
  • Haruo Tanaka
    • 1
  • Takehiko Tasaka
    • 1
  • Nobuhito Chikazawa
    • 1
  • Hiroyuki Suzuki
    • 1
  • Takashi Morisaki
    • 1
  • Makoto Kubo
    • 2
  • Hideya Onishi
    • 1
  • Masao Tanaka
    • 2
  • Mitsuo Katano
    • 1
  1. 1.Department of Cancer Therapy and Research, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Surgery and Oncology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan