Cancer Immunology, Immunotherapy

, Volume 56, Issue 6, pp 753–759

A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44

Authors

  • Danièle Godelaine
    • Ludwig Institute for Cancer Research
    • Institute of Cellular Pathology, Cellular Genetics UnitUniversité Catholique de Louvain
  • Javier Carrasco
    • Ludwig Institute for Cancer Research
    • Institute of Cellular Pathology, Cellular Genetics UnitUniversité Catholique de Louvain
  • Francis Brasseur
    • Ludwig Institute for Cancer Research
    • Institute of Cellular Pathology, Cellular Genetics UnitUniversité Catholique de Louvain
  • Bart Neyns
    • Department of Medical OncologyOncology Center
  • Kris Thielemans
    • Laboratory of PhysiologyVrije Universiteit Brussel Faculty of Medicine
  • Thierry Boon
    • Ludwig Institute for Cancer Research
    • Institute of Cellular Pathology, Cellular Genetics UnitUniversité Catholique de Louvain
    • Ludwig Institute for Cancer Research
    • Institute of Cellular Pathology, Cellular Genetics UnitUniversité Catholique de Louvain
Original Article

DOI: 10.1007/s00262-006-0244-5

Cite this article as:
Godelaine, D., Carrasco, J., Brasseur, F. et al. Cancer Immunol Immunother (2007) 56: 753. doi:10.1007/s00262-006-0244-5

Abstract

A panel of cytolytic T lymphocyte (CTL) clones was isolated from metastases and blood samples of a melanoma patient vaccinated with MAGE-3.A1-pulsed autologous dendritic cells. We report here the identification of a new antigen encoded by the MAGE-C2 cancer-germline gene. This antigen is recognized by some of these CTL on HLA-B*4403. The sequence of the peptide is SESIKKKVL. It is processed in various melanoma cell lines expressing MAGE-C2 and HLA-B*4403. Because of the expression pattern of gene MAGE-C2, this new antigen is strictly tumor-specific and could therefore be used for peptide-based antitumoral vaccination.

Keywords

Antigenic peptideCancer immunotherapyCytolytic T lymphocytesMAGEMelanoma

Copyright information

© Springer-Verlag 2006