Cancer Immunology, Immunotherapy

, Volume 54, Issue 11, pp 1043–1058

T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation

  • Johannes Schetelig
  • Alexander Kiani
  • Marc Schmitz
  • Gerhard Ehninger
  • Martin Bornhäuser
Review

DOI: 10.1007/s00262-005-0681-6

Cite this article as:
Schetelig, J., Kiani, A., Schmitz, M. et al. Cancer Immunol Immunother (2005) 54: 1043. doi:10.1007/s00262-005-0681-6

Abstract

Allogeneic hematopoietic stem cell transplantation represents the only curative approach for many hematological malignancies. During the last years the impact of the conditioning regimen has been re-assessed. With the advent of reduced-intensity conditioning the paradigm has changed from cytoreduction executed by high-dose radio-chemotherapy to immunological surveillance of leukemia by donor cells. Distinct subsets of T cells and NK cells contribute to graft-versus-leukemia reactions. So far, cytotoxic T lymphocytes are the mainstay of allogeneic immunotherapy. Here, we summarise the current knowledge of T cell-mediated graft-versus-leukemia reactions and present results from pre-clinical and clinical studies of T cell-based adoptive immunotherapy. We address the issues of feasibility and specificity of adoptive immunotransfer from a clinical point of view and discuss the prerequisites for successful clinical applications. Finally, the prospects for immunological research that have evolved with the increasing use of reduced-intensity conditioning and allogeneic stem cell transplantation are highlighted.

Keywords

Allogeneic hematopoietic stem cell transplantationReduced-intensity conditioningGraft-versus-leukemia effectsMinor histocompatibility antigensTumor antigens

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Johannes Schetelig
    • 1
  • Alexander Kiani
    • 1
  • Marc Schmitz
    • 2
  • Gerhard Ehninger
    • 1
  • Martin Bornhäuser
    • 1
  1. 1.Medizinische Klinik und Poliklinik IUniversitätsklinikum Carl Gustav CarusDresdenGermany
  2. 2.Institut für ImmunologieTechnische Universität DresdenDresdenGermany