Cancer Immunology, Immunotherapy

, Volume 54, Issue 10, pp 933–943

Targeted immunotherapy in acute myeloblastic leukemia: from animals to humans

  • Marie Robin
  • Marie-Hélène Schlageter
  • Christine Chomienne
  • Rose-Ann Padua
Review

DOI: 10.1007/s00262-005-0678-1

Cite this article as:
Robin, M., Schlageter, MH., Chomienne, C. et al. Cancer Immunol Immunother (2005) 54: 933. doi:10.1007/s00262-005-0678-1

Abstract

Immunity against acute myeloid leukemia (AML) is demonstrated in humans by the graft-versus-leukemia effect in allogeneic hematopoietic stem cell transplantation. Specific leukemic antigens have progressively been discovered and circulating specific T lymphocytes against Wilms tumor antigen, proteinase peptide or fusion-proteins produced from aberrant oncogenic chromosomal translocations have been detected in leukemic patients. However, due to the fact that leukemic blasts develop various escape mechanisms, antileukemic specific immunity is not able to control leukemic cell proliferation. The aim of immunotherapy is to overcome tolerance and boost immunity to elicit an efficient immune response against leukemia. We review different immunotherapy strategies tested in preclinical animal models of AML and the human trials that spurred from encouraging results obtained in animal models, demonstrate the feasibility of immunotherapy in AML patients.

Keywords

Acute myeloid leukemiaLeukemic specific antigenImmunotherapyDendritic cell vaccineDNA vaccine

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Marie Robin
    • 1
    • 2
  • Marie-Hélène Schlageter
    • 1
    • 3
  • Christine Chomienne
    • 1
    • 3
  • Rose-Ann Padua
    • 1
    • 4
  1. 1.LBCH INSERM U718, Hôpital Saint Louis APHPInstitut Universitaire d’HématologieParisFrance
  2. 2.Service de Greffe de MoelleHôpital Saint LouisParisFrance
  3. 3.Service de Médecine NucléaireHôpital Saint-LouisParisFrance
  4. 4.Department of Haematological MedicineKing’s College LondonUnited Kingdom
  5. 5.INSERM U718Institut Universitaire d’Hématologie, Hôpital Saint-LouisParisFrance