Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests
- Alice GillamsAffiliated withMedical Imaging, University College London Medical School and Hospitals Email author
- , Stephen PereiraAffiliated withGastroenterology, University College London Medical School and Hospitals
- , George WebsterAffiliated withGastroenterology, University College London Medical School and Hospitals
- , William LeesAffiliated withMedical Imaging, University College London Medical School and Hospitals
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To correlate MRCP quantification (MRCPQ) of pancreatic fluid output following secretin with steatorrhoea, urinary pancreo-lauryl (PL) or fecal elastase 1 (FE1) tests.
Methods and materials
Sixty-one patients, 36 male, median age 51 years (23–78) with known or suspected pancreatic disease who had undergone both MRCPQ and FE1 or PL were included. Twenty-nine patients had chronic pancreatitis, five acute pancreatitis, seven normal, five pancreas divisum, four pancreatic atrophy, three pancreatic duct obstruction, two post-surgical and six miscellaneous diagnoses. Clinical assessment of steatorrhoea was available in 29. MRCP was performed before and at 2 min intervals after 0.1 ml/kg IV Secretin. Changes in signal intensity in the imaging volume were plotted against time and the flow rate derived from the gradient. Scatter plots, Pearson correlation coefficient, and the Fisher Exact test were performed.
MRCPQ was significantly different (p = 0.012) between those with/without steatorrhoea; mean ± SD (95% CI) were 4.0 ± 1.5 (3.1:4.9, n = 16) and 6.3 ± 2.9 (4.7:7.8, n = 13). Fifty-one paired FE1-MRCPQ and 24 PL-MRCPQ data sets were analysed. Both the Pearson correlation coefficient (FE1 p = 0.001 and %TK p = 0.003) and the Fisher Exact test were significant (FE1 p = 0.016 and %T/K 0.03).
MRCPQ correlated with steatorrhoea, PL and FE1.
KeywordsMRCP Pancreatitic disease Pancreatic exocrine function Secretin Steatorrhoea
- Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests
Volume 33, Issue 4 , pp 469-473
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Pancreatitic disease
- Pancreatic exocrine function
- Industry Sectors
- Author Affiliations
- 1. Medical Imaging, University College London Medical School and Hospitals, London, United Kingdom
- 2. Gastroenterology, University College London Medical School and Hospitals, London, United Kingdom