Abdominal Imaging

, Volume 33, Issue 4, pp 417–424

Dynamic contrast enhanced magnetic resonance imaging of the terminal ileum: differentiation of activity of Crohn’s disease

Authors

    • Department of RadiologyUniversity Campus Bio-Medico
    • University Campus Bio-Medico of Rome
  • Ilaria Sansoni
    • Department of RadiologyUniversity Campus Bio-Medico
  • Renato Caviglia
    • Department of GastroenterologyUniversity Campus Bio-Medico
  • Mentore Ribolsi
    • Department of GastroenterologyUniversity Campus Bio-Medico
  • Giuseppe Perrone
    • Department of PathologyUniversity Campus Bio-Medico
  • Emanuele Leoncini
    • Medical FacultyUniversity La Sapienza
  • Rosario Francesco Grasso
    • Department of RadiologyUniversity Campus Bio-Medico
  • Michele Cicala
    • Department of GastroenterologyUniversity Campus Bio-Medico
  • Bruno Beomonte Zobel
    • Department of RadiologyUniversity Campus Bio-Medico
Article

DOI: 10.1007/s00261-007-9267-4

Cite this article as:
Del Vescovo, R., Sansoni, I., Caviglia, R. et al. Abdom Imaging (2008) 33: 417. doi:10.1007/s00261-007-9267-4

Abstract

Aim

To prospectively investigate a new high resolution MRI technique for dynamic evaluation of the enhancement kinetics of bowel parietal layers and to correlate it with CDAI, CRP, endoscopic activity and histologic features.

Methods

About 16 consecutive patients with proven diagnosis of CD underwent ileocolonoscopy with biopsy and serial bowel dynamic contrasted-MRI (D-CE-MRI) evaluated in blind fashion. Quantitative analysis of bowel wall enhancement kinetics was performed basing on signal to noise ratio (SNR) of inner parietal layers (Mucosa–Submucosa, M–SM) and outer parietal layers (Muscular–Serosa, Ms–S). Disease activity was defined by CDAI > 150, serum CRP > 5 mg/dL and histologic results.

Results

About 9 patients showed a layered enhancement of bowel wall (8 active, 1 inactive), whereas inactive (7 cases) group presented a homogeneous pattern. In active patients we found a significant difference in parietal layered enhancement curves (M–SM vs. Ms–S, P < 0.03) not observed in inactive disease and controls (intra-group analysis). M–SM and Ms–S enhanced curves in clinically active patients were significantly different respect to those of patients with inactive CD (P < 0.001) (inter-group analysis). Parietal D-CE-MRI pattern well correlated with histologic features (r = 0.8; P < 0.001, Spearman test).

Conclusions

D-CE-MRI can be a useful tool for clinical follow-up and in the treatment strategies in CD patients.

Key words:

Crohn’s diseaseDynamic MRICrohn’s disease activityBowel wall vascularityContrast enhancement

Copyright information

© Springer Science+Business Media, LLC 2007