, Volume 28, Issue 1, pp 0053-0057

Liver regeneration after living adult right lobe transplantation

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Abstract

Background: The purpose of this study was to describe liver regeneration in patients undergoing living-adult liver transplantation.

Methods: This prospective study included 10 donors and eight recipients who had a total of 65 computed tomographic (CT) scans. All patients had preoperative CT (n = 18), and follow-up CT scans (n = 47) were obtained for up to 14 months after transplantation. Liver and spleen volumes were measured by hand tracing each organ on the axial portal venous phase images.

Results: Both donors and recipients showed immediate increases in liver volume. However, liver regeneration was significantly faster and reached a higher peak in recipients than in donors. Splenic volume in donors demonstrated an initial increase followed by a decline, reaching the preoperative volume after 1 year. Splenic volume in recipients demonstrated immediate decline postoperatively.

Conclusion: Restoration of liver volume occurred rapidly after transplantation, but followed different patterns in donors and recipients. Deviation from these patterns warrants further investigation.

Received: 1 September 2001/Revision accepted: 16 November 2001