Liver regeneration after living adult right lobe transplantation
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Background: The purpose of this study was to describe liver regeneration in patients undergoing living-adult liver transplantation.
Methods: This prospective study included 10 donors and eight recipients who had a total of 65 computed tomographic (CT) scans. All patients had preoperative CT (n = 18), and follow-up CT scans (n = 47) were obtained for up to 14 months after transplantation. Liver and spleen volumes were measured by hand tracing each organ on the axial portal venous phase images.
Results: Both donors and recipients showed immediate increases in liver volume. However, liver regeneration was significantly faster and reached a higher peak in recipients than in donors. Splenic volume in donors demonstrated an initial increase followed by a decline, reaching the preoperative volume after 1 year. Splenic volume in recipients demonstrated immediate decline postoperatively.
Conclusion: Restoration of liver volume occurred rapidly after transplantation, but followed different patterns in donors and recipients. Deviation from these patterns warrants further investigation.
- Liver regeneration after living adult right lobe transplantation
Volume 28, Issue 1 , pp 0053-0057
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- Key words: Liver transplantation—Blood supply—Computed tomography—Image processing.
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- Author Affiliations
- A1. The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA, US
- A2. Institute of Liver Transplantation, Lahey Clinic Medical Center, 41 Mall Road, Burlington, MA 01805, USA, US
- A3. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA, US