European Journal of Nuclear Medicine

, Volume 25, Issue 5, pp 491–496

Optimization of X-ray mammography and technetium-99m methoxyisobutylisonitrile scintimammography in the diagnosis of non-palpable breast lesions

Authors

  • Isabel Uriarte
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Jose Manuel Carril
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Remedios Quirce
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Ceferino Gutiérrez-Mendiguchía
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Isabel Blanco
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Ignacio Banzo
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Alfonso Vega
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
  • Ana Hernández
    • Servicio de Medicina Nuclear, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Original article

DOI: 10.1007/s002590050248

Cite this article as:
Uriarte, I., Carril, J., Quirce, R. et al. Eur J Nucl Med (1998) 25: 491. doi:10.1007/s002590050248
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Abstract.

The purpose of this study was to evaluate the contribution of technetium-99m methoxyisobutylisonitrile (MIBI) scintimammography to the early diagnosis of breast cancer in 78 patients with non-palpable breast lesions detected by mammography. In all cases biopsy was indicated and they were classified into three groups according to the mammographic findings: high (28), intermediate (30) and low (20) mammographic probability of malignancy. Histological diagnosis confirmed 37 benign and 41 malignant lesions. In the high-probability group 99mTc-MIBI scintimammography changed the four false-positives into true negatives at the expense of two false-negatives; in the intermediate group it changed nine of the 17 false-positives into true-negatives at the expense of one false-negative, and in the low-probability group it changed five of the 16 false-positives into true-negatives without false-negatives. Applying scintimammography to patients included in the intermediate and low-probability groups together, 14 of the 33 mammographic false-positives were changed into true-negatives with 1 false-negative; thus, 41% of the unnecessary biopsies would have been avoided. When MIBI scintimammography was applied to the low-probability group, the negative predictive value was 100% and the unnecessary biopsies would have been reduced by 31%.

Key words: Technetium-99m methoxyisobutylisonitrileScintimammographyBreast cancerMammography
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998