European Journal of Nuclear Medicine

, Volume 28, Issue 5, pp 651–668

Carbon-11 acetate as a tracer of myocardial oxygen consumption

  • Lucas J. Klein
  • Frans C. Visser
  • Paul Knaapen
  • Job H. Peters
  • Gerrit J.J. Teule
  • Cees A. Visser
  • Adriaan A. Lammertsma
Review Article

DOI: 10.1007/s002590000472

Cite this article as:
Klein, L., Visser, F., Knaapen, P. et al. Eur J Nucl Med (2001) 28: 651. doi:10.1007/s002590000472

Abstract.

Estimation of myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, determined with positron emission tomography, allow estimation of MVO2 on a segmental level and non-invasively. In addition, MBF can be determined from uptake rates. In this review, the background to estimation of MVO2 and MBF is discussed, as well as the currently available literature that has used 11C-acetate to estimate MVO2 and MBF.

Myocardial oxygen consumption Myocardial blood flow Carbon-11 acetate Positron emission tomography 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Lucas J. Klein
    • 1
  • Frans C. Visser
    • 1
  • Paul Knaapen
    • 1
  • Job H. Peters
    • 1
  • Gerrit J.J. Teule
    • 2
  • Cees A. Visser
    • 1
  • Adriaan A. Lammertsma
    • 2
  1. 1.Department of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The NetherlandsThe Netherlands
  2. 2.Clinical PET Centre, University Hospital VU, Amsterdam, The NetherlandsThe Netherlands