Review Article

European Journal of Nuclear Medicine

, Volume 28, Issue 5, pp 651-668

First online:

Carbon-11 acetate as a tracer of myocardial oxygen consumption

  • Lucas J. KleinAffiliated withDepartment of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
  • , Frans C. VisserAffiliated withDepartment of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
  • , Paul KnaapenAffiliated withDepartment of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
  • , Job H. PetersAffiliated withDepartment of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
  • , Gerrit J.J. TeuleAffiliated withClinical PET Centre, University Hospital VU, Amsterdam, The Netherlands
  • , Cees A. VisserAffiliated withDepartment of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
  • , Adriaan A. LammertsmaAffiliated withClinical PET Centre, University Hospital VU, Amsterdam, The Netherlands

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract.

Estimation of myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, determined with positron emission tomography, allow estimation of MVO2 on a segmental level and non-invasively. In addition, MBF can be determined from uptake rates. In this review, the background to estimation of MVO2 and MBF is discussed, as well as the currently available literature that has used 11C-acetate to estimate MVO2 and MBF.

Myocardial oxygen consumption Myocardial blood flow Carbon-11 acetate Positron emission tomography