European Journal of Nuclear Medicine

, Volume 28, Issue 2, pp 191–197

Different uptake of 99mTc-ECD and 99mTc-HMPAO in the same brains: analysis by statistical parametric mapping

Authors

  • In Young Hyun
    • Department of Nuclear Medicine, Inha University College of Medicine, Incheon, Korea
  • Jae Sung Lee
    • Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungundong Chongnogu, Seoul 110-744 Korea
  • Joung Ho Rha
    • Department of Neurology, Inha University College of Medicine, Incheon, Korea
  • Il Keun Lee
    • Department of Neurology, Inha University College of Medicine, Incheon, Korea
  • Choong Kun Ha
    • Department of Neurology, Inha University College of Medicine, Incheon, Korea
  • Dong Soo Lee
    • Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungundong Chongnogu, Seoul 110-744 Korea
Original Article

DOI: 10.1007/s002590000437

Cite this article as:
Hyun, I.Y., Lee, J.S., Rha, J.H. et al. Eur J Nucl Med (2001) 28: 191. doi:10.1007/s002590000437

Abstract

The purpose of this study was to investigate the differences between technetium-99m ethyl cysteinate dimer (99mTc-ECD) and technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) uptake in the same brains by means of statistical parametric mapping (SPM) analysis. We examined 20 patients (9 male, 11 female, mean age 62±12 years) using 99mTc-ECD and 99mTc-HMPAO single-photon emission tomography (SPET) and magnetic resonance imaging (MRI) of the brain less than 7 days after onset of stroke. MRI showed no cortical infarctions. Infarctions in the pons (6 patients) and medulla (1), ischaemic periventricular white matter lesions (13) and lacunar infarction (7) were found on MRI. Split-dose and sequential SPET techniques were used for 99mTc-ECD and 99mTc-HMPAO brain SPET, without repositioning of the patient. All of the SPET images were spatially transformed to standard space, smoothed and globally normalized. The differences between the 99mTc-ECD and 99mTc-HMPAO SPET images were statistically analysed using statistical parametric mapping (SPM) 96 software. The difference between two groups was considered significant at a threshold of uncorrected P values less than 0.01. Visual analysis showed no hypoperfused areas on either 99mTc-ECD or 99mTc-HMPAO SPET images. SPM analysis revealed significantly different uptake of 99mTc-ECD and 99mTc-HMPAO in the same brains. On the 99mTc-ECD SPET images, relatively higher uptake was observed in the frontal, parietal and occipital lobes, in the left superior temporal lobe and in the superior region of the cerebellum. On the 99mTc-HMPAO SPET images, relatively higher uptake was observed in the medial temporal lobes, thalami, periventricular white matter and brain stem. These differences in uptake of the two tracers in the same brains on SPM analysis suggest that interpretation of cerebral perfusion is possible using SPET with 99mTc-ECD and 99mTc-HMPAO.

99mTc-ECD 99mTc-HMPAO Brain SPET Statistical parametric mapping

Copyright information

© Springer-Verlag 2000